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trxC reduced thioredoxin 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947062, updated on 11-Apr-2024

Summary

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Gene symbol
trxC
Gene description
reduced thioredoxin 2
Primary source
ASAP:ABE-0008501
Locus tag
b2582
See related
ECOCYC:EG11887
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2580; yfiG
Summary
OxyR regulon. [More information is available at EcoGene: EG11887]. The trxC gene encodes a second thioredoxin in Escherichia coli. [More information is available at EcoCyc: EG11887].
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Genomic context

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Sequence:
NC_000913.3 (2718735..2719154)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uracil-DNA glycosylase Neighboring gene putative methyltransferase YfiF Neighboring gene tRNA 3-amino-3-carboxypropyltransferase Neighboring gene peptidyl-lysine N-acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thioredoxin 2 from Escherichia coli is not involved in vivo in the recycling process of methionine sulfoxide reductase activities. Jacob C, et al. FEBS Lett, 2011 Jun 23. PMID 21570393
  2. Thioredoxin 2, an oxidative stress-induced protein, contains a high affinity zinc binding site. Collet JF, et al. J Biol Chem, 2003 Nov 14. PMID 12952960
  3. Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. Stewart EJ, et al. EMBO J, 1998 Oct 1. PMID 9755155, Free PMC Article
  4. Cloning, expression, and characterization of a novel Escherichia coli thioredoxin. Miranda-Vizuete A, et al. J Biol Chem, 1997 Dec 5. PMID 9388228
  5. The zinc center influences the redox and thermodynamic properties of Escherichia coli thioredoxin 2. El Hajjaji H, et al. J Mol Biol, 2009 Feb 13. PMID 19073194

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. determined the kinetic parameters of the recycling process of the three methionine sulfoxide reductases by Trx2 and the in vivo expression of Trx2 in a metB(1)trxA mutant
    Title: Thioredoxin 2 from Escherichia coli is not involved in vivo in the recycling process of methionine sulfoxide reductase activities.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase (NAD(P)H) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
reduced thioredoxin 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2718735..2719154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417077.1 reduced thioredoxin 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417077.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A830SKN8
    Conserved Domains (1) summary
    PRK10996
    Location:1 → 139
    PRK10996; thioredoxin 2; Provisional
Nucleotide Protein
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