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kgtP alpha-ketoglutarate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947069, updated on 4-Apr-2024

Summary

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Gene symbol
kgtP
Gene description
alpha-ketoglutarate:H(+) symporter
Primary source
ASAP:ABE-0008515
Locus tag
b2587
See related
ECOCYC:EG10522
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2585; witA
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG10522]. KgtP is a proton-driven transporter for -ketoglutarate. kgtP mutants show greatly impaired growth on -ketoglutarate which can be complemented by the cloned kgtP gene . [More information is available at EcoCyc: EG10522].
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Genomic context

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Sequence:
NC_000913.3 (2724448..2725746, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidyl-lysine N-acetyltransferase Neighboring gene protein PssL Neighboring gene phosphatidylserine synthase Neighboring gene DUF2279 domain-containing protein YfiM Neighboring gene protein YfiS Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane topology model of Escherichia coli alpha-ketoglutarate permease by phoA fusion analysis. Seol W, et al. J Bacteriol, 1993 Jan. PMID 8419306, Free PMC Article
  2. Site-directed mutants of Escherichia coli alpha-ketoglutarate permease (KgtP). Seol W, et al. Biochemistry, 1992 Apr 7. PMID 1554735
  3. A new gene located between pss and rrnG on the Escherichia coli chromosome. Seol W, et al. J Bacteriol, 1990 Sep. PMID 2118499, Free PMC Article
  4. Membrane transport proteins: implications of sequence comparisons. Griffith JK, et al. Curr Opin Cell Biol, 1992 Aug. PMID 1419050
  5. Sequence of the distal end of E. coli ribosomal RNA rrnG operon. Seol W, et al. Nucleic Acids Res, 1990 May 25. PMID 2190187, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables solute:monoatomic cation symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-ketoglutarate:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2724448..2725746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417082.1 alpha-ketoglutarate:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417082.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AR26, A0A827XXM7, A0A8T5ZZD5
    Conserved Domains (1) summary
    PRK10406
    Location:1 → 432
    PRK10406; alpha-ketoglutarate transporter; Provisional
Nucleotide Protein
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