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uxuA D-mannonate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947082, updated on 4-Feb-2024

Summary

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Gene symbol
uxuA
Gene description
D-mannonate dehydratase
Primary source
ASAP:ABE-0014173
Locus tag
b4322
See related
ECOCYC:EG11066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4313
Summary
UxuR regulon. [More information is available at EcoGene: EG11066]. Mannonate dehydratase catalyzes the final reaction of the glucuronate branch of the hexuronate degradation pathway . [More information is available at EcoCyc: EG11066].
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Genomic context

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Sequence:
NC_000913.3 (4551636..4552820)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene type 1 fimbriae D-mannose specific adhesin Neighboring gene fructuronate transporter Neighboring gene D-mannonate oxidoreductase Neighboring gene DNA-binding transcriptional repressor UxuR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. Qiu X, et al. J Struct Biol, 2012 Nov. PMID 22796868
  2. Colonization ability and pathogenic properties of a fim- mutant of an avian strain of Escherichia coli. Marc D, et al. Res Microbiol, 1998 Jul-Aug. PMID 9766199
  3. [Purification and properties of D-mannonate hydrolyase from Escherichia coli K12]. Robert-Baudouy JM, et al. Biochim Biophys Acta, 1973 Jun 6. PMID 4581499
  4. [Genetic mapping and biochemical characterization of mutations in the mannonic hydrolyase structural gene of Escherichia coli K 12]. Robert-Baudouy JM, et al. Mol Gen Genet, 1972. PMID 4570161
  5. Uronic acid metabolism in bacteria. III. Purification and properties of D-altronic acid and D-mannonic acid dehydrases in Escherichia coli. SMILEY JD, et al. J Biol Chem, 1960 Jun. PMID 13831814

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannonate dehydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-glucuronate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucuronate catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-mannonate dehydratase
NP_418742.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4551636..4552820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418742.1 D-mannonate dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418742.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5GXW8, A0A5B9AQA4
    Conserved Domains (1) summary
    TIGR00695
    Location:1 → 394
    uxuA; mannonate dehydratase
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases