U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pyrF orotidine-5'-phosphate decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947121, updated on 2-May-2024

Summary

Go to the top of the page Help
Gene symbol
pyrF
Gene description
orotidine-5'-phosphate decarboxylase
Primary source
ASAP:ABE-0004304
Locus tag
b1281
See related
ECOCYC:EG10809
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1276
Summary
Orotidine-5'-phosphate-decarboxylase (PyrF) catalyzes the synthesis of |FRAME: [More information is available at EcoCyc: EG10809].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1341921..1342658)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide assembly protein A Neighboring gene lipopolysaccharide assembly protein B Neighboring gene putative translation factor Neighboring gene osmotically-inducible lipoprotein OsmB Neighboring gene DNA-binding transcriptional dual regulator YciT

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Yuan J, et al. Protein Sci, 2011 Nov. PMID 21898650, Free PMC Article
  2. A substantial oxygen isotope effect at O2 in the OMP decarboxylase reaction: mechanistic implications. Wepukhulu WO, et al. Org Biomol Chem, 2008 Dec 21. PMID 19039361
  3. QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis. Stanton CL, et al. J Phys Chem B, 2007 Nov 1. PMID 17927240, Free PMC Article
  4. OMP decarboxylase--An enigma persists. Callahan BP, et al. Bioorg Chem, 2007 Dec. PMID 17889251
  5. Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase. Gao J. Curr Opin Struct Biol, 2003 Apr. PMID 12727511

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxy-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotidine-5'-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotidine-5'-phosphate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotidine-5'-phosphate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
orotidine-5'-phosphate decarboxylase
NP_415797.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1341921..1342658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415797.1 orotidine-5'-phosphate decarboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415797.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TNW0
    Conserved Domains (1) summary
    PRK00230
    Location:13 → 243
    PRK00230; orotidine-5'-phosphate decarboxylase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials