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proX glycine betaine ABC transporter periplasmic binding protein ProX [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947165, updated on 11-Apr-2024

Summary

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Gene symbol
proX
Gene description
glycine betaine ABC transporter periplasmic binding protein ProX
Primary source
ASAP:ABE-0008818
Locus tag
b2679
See related
ECOCYC:EG10773
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2673; osrA; proU
Summary
The cold-inducibility of proX is dependent on the presence of the pnp gene. [More information is available at EcoGene: EG10773]. ProVWX, the high-affinity transport system for the osmoprotectant glycine betaine, is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10773].
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Genomic context

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Sequence:
NC_000913.3 (2807132..2808124)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter membrane subunit ProW Neighboring gene pseudo Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli. Schiefner A, et al. J Biol Chem, 2004 Feb 13. PMID 14612446
  2. Functional reconstitution and osmoregulatory properties of the ProU ABC transporter from Escherichia coli. Gul N, et al. Mol Membr Biol, 2013 Mar. PMID 23249124
  3. Adaptation of Escherichia coli to high osmolarity environments: osmoregulation of the high-affinity glycine betaine transport system proU. Lucht JM, et al. FEMS Microbiol Rev, 1994 May. PMID 8011357
  4. Molecular cloning of an osmoregulatory locus in Escherichia coli: increased proU gene dosage results in enhanced osmotolerance. Gowrishankar J, et al. J Bacteriol, 1986 Dec. PMID 3536868, Free PMC Article
  5. Purification and characterization of a glycine betaine binding protein from Escherichia coli. Barron A, et al. J Biol Chem, 1987 Aug 25. PMID 3305496

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Purification and characterization of a glycine betaine binding protein from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables quaternary ammonium group binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycine betaine transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IEA
Inferred from Electronic Annotation
more info
  
part_of ProVWX complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine betaine ABC transporter periplasmic binding protein ProX
NP_417165.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2807132..2808124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417165.1 glycine betaine ABC transporter periplasmic binding protein ProX [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417165.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YKZ2, A0A8T5YIY7
    Conserved Domains (1) summary
    PRK11119
    Location:1 → 330
    proX; proline/glycine betaine ABC transporter substrate-binding protein ProX
Nucleotide Protein
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