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sdaB L-serine deaminase II [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947262, updated on 4-Apr-2024

Summary

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Gene symbol
sdaB
Gene description
L-serine deaminase II
Primary source
ASAP:ABE-0009172
Locus tag
b2797
See related
ECOCYC:EG11623
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2792
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11623]. L-serine deaminase II (SdaB) is one of three enzymes carrying out the sole step in the pathway of L-serine degradation, converting serine into a basic cellular building block, pyruvate. [More information is available at EcoCyc: EG11623].
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Genomic context

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Sequence:
NC_000913.3 (2929576..2930943)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleotide 5'-monophosphate nucleosidase Neighboring gene L-serine:H(+) symporter SdaC Neighboring gene flap endonuclease Neighboring gene L-1,2-propanediol oxidoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli. Wiebe MA, et al. mBio, 2022 Dec 20. PMID 36468870, Free PMC Article
  2. Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. Zhang X, et al. Mol Microbiol, 2008 Aug. PMID 18532981
  3. Sequencing and characterization of the sdaB gene from Escherichia coli K-12. Shao Z, et al. Eur J Biochem, 1993 Mar 15. PMID 8385012
  4. Amino acid stabilization for cell-free protein synthesis by modification of the Escherichia coli genome. Michel-Reydellet N, et al. Metab Eng, 2004 Jul. PMID 15256209
  5. Sequencing and characterization of the sdaC gene and identification of the sdaCB operon in Escherichia coli K12. Shao Z, et al. Eur J Biochem, 1994 Jun 15. PMID 8026499

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
    Title: Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-serine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
L-serine deaminase II
NP_417277.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2929576..2930943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417277.1 L-serine deaminase II [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417277.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9APC2, A0A7A7B606
    Conserved Domains (1) summary
    TIGR00720
    Location:2 → 451
    sda_mono; L-serine dehydratase, iron-sulfur-dependent, single chain form
Nucleotide Protein
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