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suhB Nus factor SuhB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947285, updated on 4-Feb-2024

Summary

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Gene symbol
suhB
Gene description
Nus factor SuhB
Primary source
ECOCYC:EG10983
Locus tag
b2533
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2530; ssyA
Summary
The N-terminal sequence was determined using protein made with a synthetic RBS, and thus is not a confirmation of the in vivo start site; the N-terminal Met was not clipped off the recombinant protein. [More information is available at EcoGene: EG10983]. The suhB gene has been shown to encode a protein with inositol monophosphatase and glycerol-2-phosphatase activity . [More information is available at EcoCyc: EG10983].
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Genomic context

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Sequence:
NC_000913.3 (2663442..2664245)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator IscR Neighboring gene tRNA Cm32/Um32 methyltransferase Neighboring gene putative peptidase Neighboring gene stationary phase-inducible protein CsiE Neighboring gene putative 3-phenylpropionate transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis. Huang YH, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31020314, Free PMC Article
  2. SuhB Associates with Nus Factors To Facilitate 30S Ribosome Biogenesis in Escherichia coli. Singh N, et al. mBio, 2016 Mar 15. PMID 26980831, Free PMC Article
  3. The structure of the R184A mutant of the inositol monophosphatase encoded by suhB and implications for its functional interactions in Escherichia coli. Wang Y, et al. J Biol Chem, 2007 Sep 14. PMID 17652087
  4. Autogenous control of the suhB gene expression of Escherichia coli. Inada T, et al. Biochimie, 1996. PMID 8831954
  5. Inositol monophosphatase activity from the Escherichia coli suhB gene product. Matsuhisa A, et al. J Bacteriol, 1995 Jan. PMID 8002619, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis.
    Title: Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis.
  2. SuhB can be integrated into a Nus factor-, and optionally ribosomal protein S4-, containing antitermination complex halted at a ribosomal antitermination signal. Furthermore, SuhB specifically binds to the acidic repeat 2 domain of the multi-domain protein NusA, an interaction that may be involved in antitermination or posttranscriptional processes.
    Title: SuhB is an integral part of the ribosomal antitermination complex and interacts with NusA.
  3. Results reveal functions of SuhB during ribosomal RNA synthesis and delineate some of the underlying molecular interactions.
    Title: Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis.
  4. The authors demonstrate that the main function of this SuhB-containing complex is not to prevent premature transcription termination within the rRNA operon, as had been long claimed, but to enable rRNA maturation and a functional ribosome fully competent for translation.
    Title: SuhB Associates with Nus Factors To Facilitate 30S Ribosome Biogenesis in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-2-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol monophosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol monophosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables lithium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA primary transcript binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription antitermination factor activity, RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription antitermination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription antitermination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nus factor SuhB
NP_417028.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2663442..2664245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417028.1 Nus factor SuhB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417028.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5N8HJQ7, A0A7A6ZVB9
    Conserved Domains (1) summary
    PRK10757
    Location:1 → 267
    PRK10757; inositol-1-monophosphatase
Nucleotide Protein
Heading Accession and Version

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