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lysA diaminopimelate decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947313, updated on 2-May-2024

Summary

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Gene symbol
lysA
Gene description
diaminopimelate decarboxylase
Primary source
ASAP:ABE-0009309
Locus tag
b2838
See related
ECOCYC:EG10549
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2836
Summary
Diaminopimelate decarboxylase (LysA) catalyzes the last step in lysine biosynthesis, converting meso-diaminopimelate to lysine. [More information is available at EcoCyc: EG10549].
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Genomic context

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Sequence:
NC_000913.3 (2977637..2978899, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator GalR Neighboring gene DNA-binding transcriptional dual regulator LysR Neighboring gene amino acid racemase YgeA Neighboring gene arabinose:H(+) symporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dimerization of Bacterial Diaminopimelate Decarboxylase Is Essential for Catalysis. Peverelli MG, et al. J Biol Chem, 2016 Apr 29. PMID 26921318, Free PMC Article
  2. Analysis of stochasticity in promoter activation by using a dual-fluorescence reporter system. Ou J, et al. Biosystems, 2009 Sep. PMID 19555736
  3. Biosynthetic interrelations of lysine, diaminopimelic acid, and threonine in mutants of Escherichia coli. DAVIS BD. Nature, 1952 Mar 29. PMID 14929228
  4. Diaminopimelic acid decarboxylase. DEWEY DL, et al. Nature, 1952 Mar 29. PMID 14929227
  5. Generation of an Escherichia coli lysA targeted deletion mutant by double cross-over recombination for potential use in a bacterial growth-based lysine assay. Li X, et al. Lett Appl Microbiol, 2003. PMID 14633099

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables diaminopimelate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diaminopimelate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diaminopimelate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via diaminopimelate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
diaminopimelate decarboxylase
NP_417315.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2977637..2978899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417315.1 diaminopimelate decarboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417315.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6L7CFU3, A0A6N0IMT7
    Conserved Domains (1) summary
    PRK11165
    Location:1 → 411
    PRK11165; diaminopimelate decarboxylase; Provisional
Nucleotide Protein
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