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mdtI multidrug/spermidine efflux pump membrane subunit MdtI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947333, updated on 11-Apr-2024

Summary

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Gene symbol
mdtI
Gene description
multidrug/spermidine efflux pump membrane subunit MdtI
Primary source
ASAP:ABE-0005343
Locus tag
b1599
See related
ECOCYC:G6857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1594; ydgE
Summary
MdtI belongs to the SMR efflux pump family, DMT superfamily. [More information is available at EcoGene: EG13926]. MdtI is part of the MdtJI spermidine SMR transporter. [More information is available at EcoCyc: G6857].
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Genomic context

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Sequence:
NC_000913.3 (1672820..1673149, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YdgU Neighboring gene putative serine protease YdgD Neighboring gene multidrug/spermidine efflux pump membrane subunit MdtJ Neighboring gene protein MdtU Neighboring gene autoinducer 2 exporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Small multidrug resistance proteins: a multidrug transporter family that continues to grow. Bay DC, et al. Biochim Biophys Acta, 2008 Sep. PMID 17942072
  2. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Paulsen IT, et al. Mol Microbiol, 1996 Mar. PMID 8730859
  3. N-acetyl-d-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli. Hirakawa H, et al. J Bacteriol, 2006 Aug. PMID 16885453, Free PMC Article
  4. Transcriptional organization and regulation of the L-idonic acid pathway (GntII system) in Escherichia coli. Bausch C, et al. J Bacteriol, 2004 Mar. PMID 14973046, Free PMC Article
  5. Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12. Sabina J, et al. J Bacteriol, 2003 Oct. PMID 14526028, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amino-acid betaine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spermidine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in choline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine betaine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermidine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermidine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of transmembrane transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
multidrug/spermidine efflux pump membrane subunit MdtI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1672820..1673149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416116.1 multidrug/spermidine efflux pump membrane subunit MdtI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416116.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5Y9B6
    Conserved Domains (1) summary
    PRK10650
    Location:1 → 109
    PRK10650; multidrug/spermidine efflux SMR transporter subunit MdtI
Nucleotide Protein
Heading Accession and Version

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