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ispB all-trans-octaprenyl-diphosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947364, updated on 4-Apr-2024

Summary

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Gene symbol
ispB
Gene description
all-trans-octaprenyl-diphosphate synthase
Primary source
ASAP:ABE-0010474
Locus tag
b3187
See related
ECOCYC:EG10017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cel; ECK3176; yhbD
Summary
Octaprenyl diphosphate (OPP) synthase catalyzes the condensation reactions resulting in the formation of OPP, the isoprenoid side chain of |FRAME: [More information is available at EcoCyc: EG10017].
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Genomic context

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Sequence:
NC_000913.3 (3333710..3334681)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L27 Neighboring gene 50S ribosomal subunit protein L21 Neighboring gene putative transcriptional regulator SfsB Neighboring gene UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli. Li X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Mar 1. PMID 23519815, Free PMC Article
  2. Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. Guo RT, et al. Acta Crystallogr D Biol Crystallogr, 2003 Dec. PMID 14646090
  3. Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis. Pan JJ, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825609
  4. The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli. Okada K, et al. J Bacteriol, 1997 May. PMID 9139929, Free PMC Article
  5. The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase. Asai K, et al. Biochem Biophys Res Commun, 1994 Jul 15. PMID 8037730

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispB(R321A) mutant and restored IspB activity and production of Coenzyme Q-8.
    Title: A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables octaprenyl pyrophosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prenyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polyprenol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
all-trans-octaprenyl-diphosphate synthase
NP_417654.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3333710..3334681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417654.1 all-trans-octaprenyl-diphosphate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417654.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5D8MT80, A0AA88EKG6
    Conserved Domains (1) summary
    PRK10888
    Location:1 → 323
    PRK10888; octaprenyl diphosphate synthase; Provisional
Nucleotide Protein
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