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mscS small conductance mechanosensitive channel MscS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947416, updated on 2-May-2024

Summary

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Gene symbol
mscS
Gene description
small conductance mechanosensitive channel MscS
Primary source
ASAP:ABE-0009595
Locus tag
b2924
See related
ECOCYC:EG11160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2920; yggB
Summary
HT_Cmplx47_Mem: [More information is available at EcoGene: EG11160]. MscS is one of four classes of Escherichia coli mechanosensitive (MS) channels. [More information is available at EcoCyc: EG11160].
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Genomic context

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Sequence:
NC_000913.3 (3068947..3069807, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF541 domain-containing protein YggE Neighboring gene L-arginine exporter Neighboring gene fructose-bisphosphate aldolase class II Neighboring gene phosphoglycerate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels. Park YC, et al. Elife, 2023 Jan 30. PMID 36715097, Free PMC Article
  2. Voltage-Dependent Inactivation of MscS Occurs Independently of the Positively Charged Residues in the Transmembrane Domain. Nomura T, et al. Biomed Res Int, 2016. PMID 28101504, Free PMC Article
  3. The role of lipids in mechanosensation. Pliotas C, et al. Nat Struct Mol Biol, 2015 Dec. PMID 26551077, Free PMC Article
  4. Mutations in a Conserved Domain of E. coli MscS to the Most Conserved Superfamily Residue Leads to Kinetic Changes. Malcolm HR, et al. PLoS One, 2015. PMID 26340270, Free PMC Article
  5. Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes. Nomura T, et al. FASEB J, 2015 Oct. PMID 26116700

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels.
    Title: State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels.
  2. Interaction between mechanosensitive channels embedded in lipid membrane.
    Title: Interaction between mechanosensitive channels embedded in lipid membrane.
  3. inactivation process of wild-type MscS was strongly affected by voltage. The wild-type MscS inactivated at +60 to +80 mV but not at -60 to +40 mV.
    Title: Voltage-Dependent Inactivation of MscS Occurs Independently of the Positively Charged Residues in the Transmembrane Domain.
  4. Mutations in a conserved domain of E. coli MscS to the most conserved superfamily residue leads to kinetic changes.
    Title: Mutations in a Conserved Domain of E. coli MscS to the Most Conserved Superfamily Residue Leads to Kinetic Changes.
  5. Molecular dynamics and biophysical analyses show that the volume of the pockets and thus the number of lipid acyl chains within them decreases upon channel opening.
    Title: The role of lipids in mechanosensation.
  6. Data show that trifluoroethanol (TFE) affects mechanosensitive channel of small conductance (MscS) channel gating kinetics in spheroplasts and liposomes.
    Title: Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes.
  7. Data indicate that mechanosensitive channel of small conductance (MscS) protein opens in response to a relief of intrinsic lipid bilayer pressure.
    Title: The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.
  8. We report here crystal structures of MscS from E. coli and Helicobacter pylori solubilized in the detergent beta-dodecylmaltoside at resolutions of 4.4 and 4.2 A, respectively.
    Title: Open and shut: crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from Escherichia coli and Helicobacter pylori at 4.4 Å and 4.1 Å resolutions.
  9. Article reviews the science that led to the isolation and identification of MscS. structure-function relationship of the channel, in particular the structural and biochemical approaches to understanding channel gating. [Review]
    Title: Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.
  10. Data show that the MscL/MscS threshold ratio dramatically decreased in thinner compared with thicker bilayers.
    Title: Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small conductance mechanosensitive channel MscS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3068947..3069807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417399.1 small conductance mechanosensitive channel MscS [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417399.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A793CB35
    Conserved Domains (1) summary
    PRK10334
    Location:1 → 286
    PRK10334; small-conductance mechanosensitive channel MscS
Nucleotide Protein
Heading Accession and Version

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