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gpr L-glyceraldehyde 3-phosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947480, updated on 23-Nov-2023

Summary

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Gene symbol
gpr
Gene description
L-glyceraldehyde 3-phosphate reductase
Primary source
ASAP:ABE-0009848
Locus tag
b3001
See related
ECOCYC:G7558
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2995; mgrA; yghZ
Summary
AKR14 family. [More information is available at EcoGene: EG13010]. YghZ is an L-glyceraldehyde 3-phosphate (L-GAP) reductase ; the enzyme is also able to detoxify methylglyoxal at a low rate . [More information is available at EcoCyc: G7558].
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Genomic context

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Sequence:
NC_000913.3 (3147897..3148937)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2623 domain-containing protein YghW Neighboring gene pseudo Neighboring gene protein YqhI Neighboring gene UPF0114 family protein YqhA Neighboring gene NADP(+)-dependent aldehyde reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. L-glyceraldehyde 3-phosphate reductase from Escherichia coli is a heme binding protein. Desai KK, et al. Bioorg Chem, 2010 Feb. PMID 20015532
  2. Metabolism of L-glyceraldehyde 3-phosphate in Escherichia coli. Kalyananda MK, et al. J Bacteriol, 1987 Jun. PMID 3294792, Free PMC Article
  3. Restoring a metabolic pathway. Richard JP. ACS Chem Biol, 2008 Oct 17. PMID 18928248
  4. L-Glyceraldehude 3-phosphate, a bactericidal agent. Tang CT, et al. Antimicrob Agents Chemother, 1977 Jan. PMID 319747, Free PMC Article
  5. Bacterial production of methylglyoxal: a survival strategy or death by misadventure? Booth IR, et al. Biochem Soc Trans, 2003 Dec. PMID 14641075

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in methylglyoxal catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methylglyoxal catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylglyoxal catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
L-glyceraldehyde 3-phosphate reductase
NP_417474.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3147897..3148937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417474.1 L-glyceraldehyde 3-phosphate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417474.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QIA0
    Conserved Domains (1) summary
    PRK09912
    Location:1 → 346
    PRK09912; L-glyceraldehyde 3-phosphate reductase; Provisional
Nucleotide Protein
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