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kdpC K(+) transporting P-type ATPase subunit KdpC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947508, updated on 4-Feb-2024

Summary

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Gene symbol
kdpC
Gene description
K(+) transporting P-type ATPase subunit KdpC
Primary source
ASAP:ABE-0002374
Locus tag
b0696
See related
ECOCYC:EG10515
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0684; kac
Summary
The kdpFABC genes encode an ATP-dependent high affinity P-Type ATPase potassium ion transporter . [More information is available at EcoCyc: EG10515].
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Genomic context

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Sequence:
NC_000913.3 (724407..724979, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene leader peptide SpeFL Neighboring gene DNA-binding transcriptional activator KdpE Neighboring gene sensor histidine kinase KdpD Neighboring gene K(+) transporting P-type ATPase subunit KdpB Neighboring gene K(+) transporting P-type ATPase subunit KdpA Neighboring gene K(+) transporting P-type ATPase subunit KdpF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The KdpC subunit of the Escherichia coli K+-transporting KdpB P-type ATPase acts as a catalytic chaperone. Irzik K, et al. FEBS J, 2011 Sep. PMID 21711450
  2. ATP binding properties of the soluble part of the KdpC subunit from the Escherichia coli K(+)-transporting KdpFABC P-type ATPase. Ahnert F, et al. Biochemistry, 2006 Sep 12. PMID 16953591
  3. FITC binding site and p-nitrophenyl phosphatase activity of the Kdp-ATPase of Escherichia coli. Bramkamp M, et al. Biochemistry, 2004 Apr 20. PMID 15078102
  4. ATP-driven potassium transport in right-side-out membrane vesicles via the Kdp system of Escherichia coli. Kollmann R, et al. Biochim Biophys Acta, 1993 Jun 10. PMID 8499455
  5. Identification of the structural proteins of an ATP-driven potassium transport system in Escherichia coli. Laimins LA, et al. Proc Natl Acad Sci U S A, 1978 Jul. PMID 356049, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for potassium transport in prokaryotes by KdpFABC.
    Title: Structural basis for potassium transport in prokaryotes by KdpFABC.
  2. Data indicate that KdpFABC P-type ATPase activity could be stimulated not only by the presence of the transported K+ ions in a pH-dependent manner but also, to a significantly lesser extent, by H+ and Na+.
    Title: Mechanistic analysis of the pump cycle of the KdpFABC P-type ATPase.
  3. Data suggest that high-affinity ATP binding to KdpFABC is dependent on conserved Gln in KdpC; that ATP binding to KdpC and ATP hydrolysis by KdpFABC are sensitive to accessibility of ribose hydroxyls; and that KdpC binds with KdpB ATP-binding loop.
    Title: The KdpC subunit of the Escherichia coli K+-transporting KdpB P-type ATPase acts as a catalytic chaperone.
  4. Data show that the increase in the anionic lipid composition enhances the expression rate of the kdpFABC operon.
    Title: Influence of K+-dependent membrane lipid composition on the expression of the kdpFABC operon in Escherichia coli.
  5. review K+-translocating KdpFABC complex: KdpC might act as a catalytical chaperone, which cooperatively interacts with the nucleotide to be hydrolyzed
    Title: The K+-translocating KdpFABC complex from Escherichia coli: a P-type ATPase with unique features.
  6. ATP binding occurred within the Val144-Lys161 peptide located within the C-terminal part of KdpC
    Title: ATP binding properties of the soluble part of the KdpC subunit from the Escherichia coli K(+)-transporting KdpFABC P-type ATPase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables P-type potassium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type potassium transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type potassium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
part_of potassium ion-transporting ATPase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of potassium:proton antiporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
K(+) transporting P-type ATPase subunit KdpC
NP_415224.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    724407..724979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415224.1 K(+) transporting P-type ATPase subunit KdpC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415224.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JLF8
    Conserved Domains (1) summary
    PRK00315
    Location:1 → 188
    PRK00315; potassium-transporting ATPase subunit KdpC
Nucleotide Protein
Heading Accession and Version

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