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nfeF NADPH-dependent ferric-chelate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947582, updated on 6-Oct-2023

Summary

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Gene symbol
nfeF
Gene description
NADPH-dependent ferric-chelate reductase
Primary source
ASAP:ABE-0010079
Locus tag
b3070
See related
ECOCYC:G7593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3060; yqjH
Summary
Expression of yqjH may be regulated by Fur; a candidate FUR box has been found upstream of the ORF . [More information is available at EcoCyc: G7593].
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Genomic context

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Sequence:
NC_000913.3 (3215727..3216491, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene stationary phase mismatch/uracil DNA glycosylase Neighboring gene tRNA-Ile Neighboring gene DNA-binding transcriptional repressor NfeR Neighboring gene aerotaxis receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Miethke M, et al. Biochemistry, 2011 Dec 20. PMID 22098718
  2. Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase. Bamford VA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Sep 1. PMID 18765906, Free PMC Article
  3. Comparative analysis of FUR regulons in gamma-proteobacteria. Panina EM, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812853, Free PMC Article
  4. Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli. Wang S, et al. J Bacteriol, 2011 Jan. PMID 21097627, Free PMC Article
  5. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. McHugh JP, et al. J Biol Chem, 2003 Aug 8. PMID 12746439

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Site-directed mutagenesis reveals that residues K55 and R130 are crucial for substrate binding and ferric reductase activity. Catalytic/structural analysis: substrate specificity, kinetic analysis, reaction mechanism, amino acid sequence alignment.
    Title: The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli.
  2. The authors show that YqjH has ferric reductase activity and is required for iron homeostasis in Escherichia coli.
    Title: Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
NADPH-dependent ferric-chelate reductase
NP_417541.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3215727..3216491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417541.1 NADPH-dependent ferric-chelate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417541.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N0IM67
    Conserved Domains (1) summary
    COG2375
    Location:1 → 254
    ViuB; NADPH-dependent ferric siderophore reductase, contains FAD-binding and SIP domains [Inorganic ion transport and metabolism]
Nucleotide Protein
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