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uxaC D-glucoronate/D-galacturonate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947599, updated on 4-Apr-2024

Summary

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Gene symbol
uxaC
Gene description
D-glucoronate/D-galacturonate isomerase
Primary source
ASAP:ABE-0010167
Locus tag
b3092
See related
ECOCYC:G81
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3083; ygjX; ygjY; ygjZ
Summary
Uronate isomerase catalyzes the initial step of isomerization of the alduronic to the keturonic acid in the glucuronate and galacturonate degradation pathways. [More information is available at EcoCyc: G81].
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Genomic context

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Sequence:
NC_000913.3 (3243329..3244741, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein Neighboring gene D-altronate dehydratase Neighboring gene hexuronate transporter Neighboring gene DNA-binding transcriptional repressor ExuR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily. Nguyen TT, et al. Biochemistry, 2009 Sep 22. PMID 19678710, Free PMC Article
  2. Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli. ASHWELL G, et al. J Biol Chem, 1960 Jun. PMID 13794771
  3. Studies on a D-galacturonic acid isomerase. TAKAGI Y, et al. Biochim Biophys Acta, 1959 Jan. PMID 13628636
  4. [Individuality of D glucuronate-ketol isomerase from K 12 Escherichia coli]. Novel G, et al. Biochimie, 1973. PMID 4594308
  5. [Studies of mutations in the uronic isomerase and altronic oxidoreductase structural genes of Escherichia coli K 12 (author's transl)]. Portalier RC, et al. Mol Gen Genet, 1974. PMID 4594010

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glucuronate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-galacturonate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-galacturonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-glucuronate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-glucuronate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucuronate catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-glucoronate/D-galacturonate isomerase
NP_417563.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3243329..3244741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417563.1 D-glucoronate/D-galacturonate isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417563.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA94SGA6
    Conserved Domains (1) summary
    PRK02925
    Location:1 → 468
    PRK02925; glucuronate isomerase; Reviewed
Nucleotide Protein
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