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murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947703, updated on 2-May-2024

Summary

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Gene symbol
murA
Gene description
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Primary source
ASAP:ABE-0010479
Locus tag
b3189
See related
ECOCYC:EG11358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3178; mrbA; murZ
Summary
murA is an essential gene. [More information is available at EcoGene: EG11358].
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Genomic context

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Sequence:
NC_000913.3 (3335235..3336494, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene all-trans-octaprenyl-diphosphate synthase Neighboring gene putative transcriptional regulator SfsB Neighboring gene acid stress protein IbaG Neighboring gene intermembrane phospholipid transport system protein MlaB Neighboring gene intermembrane phospholipid transport system - periplasmic binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibitory mechanism of the Qβ lysis protein A2. Reed CA, et al. Mol Microbiol, 2012 Nov. PMID 22934834, Free PMC Article
  2. Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions . Jackson SG, et al. Biochemistry, 2009 Dec 15. PMID 19899805
  3. The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography. Steinbach A, et al. J Med Chem, 2008 Aug 28. PMID 18672863
  4. 2-Aminotetralones: novel inhibitors of MurA and MurZ. Dunsmore CJ, et al. Bioorg Med Chem Lett, 2008 Mar 1. PMID 18261901
  5. Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bachelier A, et al. Bioorg Med Chem Lett, 2006 Nov 1. PMID 16945528

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The lysis protein A2 of enterobacteria phage Qbeta preferentially binds bacterial MurA liganded with UDP-NAG, thereby preventing catalysis by occluding PEP from accessing the active site.
    Title: Inhibitory mechanism of the Qβ lysis protein A2.
  2. The kinetics of MurA-catalyzed tetrahedral intermediate partitioning provides functional evidence of the relevance of MurA's conformationally restricted active site as part of a choreographed product dissociation process.
    Title: Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions .
  3. MurA catalyzed the formation of a covalent adduct between its inhibitor, cnicin and its substrate UDP-N-acetylglucosamine.
    Title: The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography.
  4. N-terminus verified by Edman degradation on complete protein
    Title: Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylgalactosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
NP_417656.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3335235..3336494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417656.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417656.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9APN3, A0A826TA67
    Conserved Domains (1) summary
    PRK09369
    Location:1 → 416
    PRK09369; UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases