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speD S-adenosylmethionine decarboxylase proenzyme [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947719, updated on 4-Apr-2024

Summary

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Gene symbol
speD
Gene description
S-adenosylmethionine decarboxylase proenzyme
Primary source
ASAP:ABE-0000416
Locus tag
b0120
See related
ECOCYC:EG10962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0119
Summary
Paraquat toxicity observed in cells deficient in spermidine. [More information is available at EcoGene: EG10962]. Adenosylmethionine decarboxylase is first synthesized as a proenzyme which is cleaved post-translationally into two smaller polypeptides. [More information is available at EcoCyc: EG10962].
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Genomic context

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Sequence:
NC_000913.3 (134788..135582, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene AcnB Neighboring gene PF06062 family protein YacL Neighboring gene spermidine synthase Neighboring gene putative lipoprotein YacC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metal ion activation of S-adenosylmethionine decarboxylase reflects cation charge density. Lu ZJ, et al. Biochemistry, 2007 Jul 10. PMID 17567041
  2. S-adenosylmethionine decarboxylase of Escherichia coli. Studies on the covalently linked pyruvate required for activity. Markham GD, et al. J Biol Chem, 1982 Oct 25. PMID 6749853
  3. Escherichia coli S-adenosylmethionine decarboxylase. Subunit structure, reductive amination, and NH2-terminal sequences. Anton DL, et al. J Biol Chem, 1987 Feb 25. PMID 3546296
  4. Escherichia coli mutants completely deficient in adenosylmethionine decarboxylase and in spermidine biosynthesis. Tabor CW, et al. J Biol Chem, 1978 May 25. PMID 348695
  5. The speEspeD operon of Escherichia coli. Formation and processing of a proenzyme form of S-adenosylmethionine decarboxylase. Tabor CW, et al. J Biol Chem, 1987 Nov 25. PMID 3316212

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Escherichia coli S-adenosylmethionine decarboxylase. Subunit structure, reductive amination, and NH2-terminal sequences.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables adenosylmethionine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylmethionine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosylmethionine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within self proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
S-adenosylmethionine decarboxylase proenzyme
NP_414662.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    134788..135582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414662.1 S-adenosylmethionine decarboxylase proenzyme [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414662.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827XTR2
    Conserved Domains (1) summary
    PRK05462
    Location:1 → 264
    PRK05462; adenosylmethionine decarboxylase
Nucleotide Protein
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