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trkA NAD-binding component of Trk potassium transporters [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947788, updated on 23-Nov-2023

Summary

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Gene symbol
trkA
Gene description
NAD-binding component of Trk potassium transporters
Primary source
ASAP:ABE-0010787
Locus tag
b3290
See related
ECOCYC:EG11019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3276
Summary
Although normally required for Trk activity, overproduction of TrkG or TrkH alone increases K+ transport in a trkA mutant strain (Buurman, 2004). [More information is available at EcoGene: EG11019]. trkA mutants were identified in a kdp background as requiring significantly elevated levels of K+ for growth . trkA encodes part of a K+ transport system . [More information is available at EcoCyc: EG11019].
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Genomic context

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Sequence:
NC_000913.3 (3436518..3437894)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase Neighboring gene 16S rRNA m(5)C967 methyltransferase Neighboring gene large conductance mechanosensitive channel Neighboring gene alternative ribosome-rescue factor A Neighboring gene DNA-binding transcriptional activator ZntR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Formate increases the F0F1-ATPase activity in Escherichia coli growing on glucose under anaerobic conditions at slightly alkaline pH. Bagramyan K, et al. Biochem Biophys Res Commun, 2003 Jun 27. PMID 12804571
  2. Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase. Meinnel T, et al. J Bacteriol, 1994 Dec. PMID 7961514, Free PMC Article
  3. The regulation of potassium fluxes for the adjustment and maintenance of potassium levels in Escherichia coli. Meury J, et al. Eur J Biochem, 1981 Sep. PMID 7042336
  4. The effects of weak acids on potassium uptake by Escherichia coli K-12 inhibition by low cytoplasmic pH. Bakker EP, et al. Biochim Biophys Acta, 1983 May 5. PMID 6405784
  5. Physical mapping of the K+ transport trkA gene of Escherichia coli and overproduction of the TrkA protein. Hamann A, et al. J Bacteriol, 1987 Jul. PMID 3298214, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. although lagging-strand synthesis is still perturbed in holD trkA mutants, the trkA mutation allows HolD-less Pol III HE to resist increased levels of the SOS-induced bypass polymerase DinB
    Title: Mutations Affecting Potassium Import Restore the Viability of the Escherichia coli DNA Polymerase III holD Mutant.
  2. Complementation experiments revealed that Aa-TrkA and Aa-TrkH from A. amylolytica strain N10 restored the ability to grow at low K(+) concentration in E. coli DeltatrkA and DeltatrkG DeltatrkH strains, respectively.
    Title: Characterization and function analysis of a Halo-alkaline-adaptable Trk K+ uptake system in Alkalimonas amylolytica strain N10.
  3. N-terminus verified by Edman degradation on complete protein
    Title: NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport.
  4. IIANtr regulates the K+ transporter TrkA
    Title: Escherichia coli enzyme IIANtr regulates the K+ transporter TrkA.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAD-binding component of Trk potassium transporters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3436518..3437894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417748.1 NAD-binding component of Trk potassium transporters [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417748.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5D8M313, A0A831GTI0
    Conserved Domains (1) summary
    PRK09496
    Location:1 → 456
    trkA; Trk system potassium transporter TrkA
Nucleotide Protein
Heading Accession and Version

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Other Literature Sources
Molecular Biology Databases
Research Materials