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kefB K(+) : H(+) antiporter KefB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947858, updated on 11-Apr-2024

Summary

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Gene symbol
kefB
Gene description
K(+) : H(+) antiporter KefB
Primary source
ASAP:ABE-0010949
Locus tag
b3350
See related
ECOCYC:EG20110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3338; trkB
Summary
KefB and KefC are two independent glutathione-regulated potassium efflux systems, which play a role in protecting the cell from electrophile toxicity. [More information is available at EcoCyc: EG20110].
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Genomic context

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Sequence:
NC_000913.3 (3478802..3480607, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene FKBP-type peptidyl-prolyl cis-trans isomerase SlyD Neighboring gene DUF2387 domain-containing protein YheV Neighboring gene glutathione-regulated potassium-efflux system ancillary protein KefG Neighboring gene putative ATP-binding protein YheS Neighboring gene putative hydrolase YheT Neighboring gene PF06794 family protein YheU

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Different foci for the regulation of the activity of the KefB and KefC glutathione-gated K+ efflux systems. Ness LS, et al. J Biol Chem, 1999 Apr 2. PMID 10092637
  2. Potassium channel activation by glutathione-S-conjugates in Escherichia coli: protection against methylglyoxal is mediated by cytoplasmic acidification. Ferguson GP, et al. Mol Microbiol, 1995 Sep. PMID 8594323
  3. Activation of potassium channels during metabolite detoxification in Escherichia coli. Ferguson GP, et al. Mol Microbiol, 1993 Sep. PMID 7934942
  4. Roles of the trkB and trkC gene products of Escherichia coli in K+ transport. Booth IR, et al. Biochimie, 1985 Jan. PMID 3888294
  5. Evidence for multiple K+ export systems in Escherichia coli. Bakker EP, et al. J Bacteriol, 1987 Aug. PMID 3301813, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione-regulated potassium exporter activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of potassium:proton antiporter complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
K(+) : H(+) antiporter KefB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3478802..3480607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417809.1 K(+) : H(+) antiporter KefB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417809.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ACT6, A0A8T5YDC0
    Conserved Domains (1) summary
    PRK03659
    Location:1 → 600
    PRK03659; glutathione-regulated potassium-efflux system protein KefB; Provisional
Nucleotide Protein
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