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cysG siroheme synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947880, updated on 2-May-2024

Summary

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Gene symbol
cysG
Gene description
siroheme synthase
Primary source
ASAP:ABE-0011010
Locus tag
b3368
See related
ECOCYC:EG10188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3356
Summary
YraL is homologous to the C-terminal methyltransferase domain of CysG. cysG is transcribed from the nirB operon and from cysG promoters. [More information is available at EcoGene: EG10188]. The Escherichia coli |FRAME: [More information is available at EcoCyc: EG10188].
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Genomic context

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Sequence:
NC_000913.3 (3497828..3499201)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nitrite reductase (NADH) large subunit Neighboring gene nitrite reductase (NADH) small subunit Neighboring gene nitrite transporter NirC Neighboring gene DUF4223 domain-containing lipoprotein YhfL Neighboring gene fructoselysine/psicoselysine transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis. Woodcock SC, et al. Biochem J, 1998 Feb 15. PMID 9461500, Free PMC Article
  2. Evidence for a covalent intermediate in the S-adenosyl-L-methionine-dependent transmethylation reaction catalysed by sirohaem synthase. Woodcock SC, et al. Biochem J, 1996 Jan 15. PMID 8573073, Free PMC Article
  3. The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthase. Spencer JB, et al. FEBS Lett, 1993 Nov 29. PMID 8243665
  4. Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein. Warren MJ, et al. Biochem J, 1994 Sep 15. PMID 7945210, Free PMC Article
  5. Biochemical and genetic characterization of nirB mutants of Escherichia coli K 12 pleiotropically defective in nitrite and sulphite reduction. Cole JA, et al. J Gen Microbiol, 1980 Oct. PMID 6262434

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Enzymatic synthesis of dihydrosirohydrochlorin (precorrin-2) and of a novel pyrrocorphin by uroporphyrinogen III methylase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables precorrin-2 dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sirohydrochlorin ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
enables uroporphyrin-III C-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uroporphyrin-III C-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uroporphyrin-III C-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siroheme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siroheme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
siroheme synthase
NP_417827.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3497828..3499201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417827.1 siroheme synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417827.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3P5DV28, A0A8S7EAT8
    Conserved Domains (1) summary
    PRK10637
    Location:1 → 457
    cysG; siroheme synthase CysG
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials