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malQ 4-alpha-glucanotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947923, updated on 6-Oct-2023

Summary

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Gene symbol
malQ
Gene description
4-alpha-glucanotransferase
Primary source
ASAP:ABE-0011151
Locus tag
b3416
See related
ECOCYC:EG10561
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3403; malA
Summary
MalT regulon. [More information is available at EcoGene: EG10561]. Amylomaltase was first described as a maltose-inducible enzyme that catalyzes a reversible transglycosidase reaction . [More information is available at EcoCyc: EG10561].
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Genomic context

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Sequence:
NC_000913.3 (3547986..3550070, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster carrier protein NfuA Neighboring gene high-affinity gluconate transporter Neighboring gene maltodextrin phosphorylase Neighboring gene DNA-binding transcriptional activator MalT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the Transglycosylation Reaction of 4-α-Glucanotransferase (MalQ) and Its Role in Glycogen Breakdown in Escherichia coli. Nguyen DHD, et al. J Microbiol Biotechnol, 2019 Mar 28. PMID 30691252
  2. Direct utilization of maltose by Escherichia coli. DOUDOROFF M, et al. J Biol Chem, 1949 Jun. PMID 18150023
  3. [Amylomaltase of Escherichia coli]. MONOD J, et al. Ann Inst Pasteur (Paris), 1950 Jan. PMID 15413815
  4. The characterization of the pathway of maltose utilization by Escherichia coli. II. General properties and mechanism of action of amylomaltase. WIESMEYER H, et al. Biochim Biophys Acta, 1960 Apr 22. PMID 13844669
  5. The characterization of the pathway of maltose utilization by Escherichia coli. I. Purification and physical chemical properties of the enzyme amylomaltase. WIESMEYER H, et al. Biochim Biophys Acta, 1960 Apr 22. PMID 13844668

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The action of MalQ on maltose or maltodextrin can lead to the formation of glycogen and that MalP controls (inhibits) this pathway.
    Title: Role of maltose enzymes in glycogen synthesis by Escherichia coli.
  2. The fact that glk malQ+ mutants showed elevated mal gene expression finds its explanation in the reduced ability to remove glucose from MalQ-catalyzed maltodextrin formation and is caused by a metabolically induced MalQ- phenotype.
    Title: Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.
  3. A comparison of ATPHS2 and DPE2 from A. thaliana with MalP and MalQ from E. coli is presented.
    Title: The role of cytosolic alpha-glucan phosphorylase in maltose metabolism and the comparison of amylomaltase in Arabidopsis and Escherichia coli.
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Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-alpha-glucanotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-alpha-glucanotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-maltose 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maltose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within maltose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
4-alpha-glucanotransferase
NP_417875.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3547986..3550070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417875.1 4-alpha-glucanotransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417875.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376WSK2, A0A6M9WXH2
    Conserved Domains (1) summary
    PRK11052
    Location:1 → 684
    malQ; 4-alpha-glucanotransferase; Provisional
Nucleotide Protein
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