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livK L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947964, updated on 11-Apr-2024

Summary

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Gene symbol
livK
Gene description
L-leucine/L-phenylalanine ABC transporter periplasmic binding protein
Primary source
ASAP:ABE-0011292
Locus tag
b3458
See related
ECOCYC:EG10540
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3442; hrbB; hrbC; hrbD
Summary
The crystal structure of LivK in both the apo- and ligand-bound form has been determined at 1.5 and 1.8 A resolution . [More information is available at EcoCyc: EG10540].
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Genomic context

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Sequence:
NC_000913.3 (3596451..3597560, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH Neighboring gene PanD maturation factor Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 19F NMR study of the leucine-specific binding protein of Escherichia coli: mutagenesis and assignment of the 5-fluorotryptophan-labeled residues. Salopek-Sondi B, et al. Protein Eng, 2002 Nov. PMID 12538904
  2. Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and the mature form. Oxender DL, et al. Proc Natl Acad Sci U S A, 1980 Apr. PMID 6990419, Free PMC Article
  3. Structure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structure. Sack JS, et al. J Mol Biol, 1989 Mar 5. PMID 2649683
  4. Chemisorptions of bacterial receptors for hydrophobic amino acids and sugars on gold for biosensor applications: a surface plasmon resonance study of genetically engineered proteins. Luck LA, et al. Biosens Bioelectron, 2003 Nov 30. PMID 14611761
  5. Exploring the role of amino acid-18 of the leucine binding proteins of E. coli. Salopek-Sondi B, et al. J Biomol Struct Dyn, 2002 Dec. PMID 12437376

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-leucine binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-leucine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in phenylalanine transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
L-leucine/L-phenylalanine ABC transporter periplasmic binding protein
NP_417915.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3596451..3597560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417915.1 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417915.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ACH1
    Conserved Domains (1) summary
    PRK15404
    Location:1 → 369
    PRK15404; high-affinity branched-chain amino acid ABC transporter substrate-binding protein
Nucleotide Protein
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