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glyQ glycine--tRNA ligase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948079, updated on 2-May-2024

Summary

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Gene symbol
glyQ
Gene description
glycine--tRNA ligase subunit alpha
Primary source
ASAP:ABE-0011626
Locus tag
b3560
See related
ECOCYC:EG10409
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cfcA; ECK3548; glyS(A)
Summary
Glycyl-tRNA synthetase (GlyRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10409].
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Genomic context

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Sequence:
NC_000913.3 (3724407..3725318, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene glycine--tRNA ligase subunit beta Neighboring gene putative lipoprotein YsaB Neighboring gene O-acetyltransferase WecH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters. Toth MJ, et al. J Biol Chem, 1990 Jan 15. PMID 2295596
  2. Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) controls the timing of cell division in Escherichia coli. Nishimura A, et al. Genes Cells, 1997 Jun. PMID 9286857
  3. Cell growth inhibition by sequence-specific RNA minihelices. Hipps D, et al. EMBO J, 1995 Aug 15. PMID 7664744, Free PMC Article
  4. Overproduction, purification, and subunit structure of Escherichia coli glycyl transfer ribonucleic acid synthetase. McDonald T, et al. Biochemistry, 1980 Apr 1. PMID 6992865
  5. The beta subunit of E. coli glycyl-tRNA synthetase plays a major role in tRNA recognition. Nagel GM, et al. Nucleic Acids Res, 1984 May 25. PMID 6374618, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to glycine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glycine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glycine-tRNA ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
glycine--tRNA ligase subunit alpha
NP_418017.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3724407..3725318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418017.1 glycine--tRNA ligase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418017.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EAE3
    Conserved Domains (1) summary
    PRK09348
    Location:5 → 292
    glyQ; glycyl-tRNA synthetase subunit alpha; Validated
Nucleotide Protein
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Research Materials