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mtlA mannitol-specific PTS enzyme IICBA component [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948118, updated on 2-May-2024

Summary

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Gene symbol
mtlA
Gene description
mannitol-specific PTS enzyme IICBA component
Primary source
ASAP:ABE-0011761
Locus tag
b3599
See related
ECOCYC:EG10615
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3588; mtlC
Summary
[More information is available at EcoCyc: EG10615].
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Genomic context

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Sequence:
NC_000913.3 (3772281..3774194)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein YibH Neighboring gene DUF3302 domain-containing protein YibI Neighboring gene mannitol-1-phosphate 5-dehydrogenase Neighboring gene transcriptional repressor MtlR Neighboring gene protein YibT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the cytoplasmic loop between putative helices II and III of the mannitol permease of Escherichia coli: a tryptophan and 5-fluorotryptophan spectroscopy study. Vos EP, et al. Biochemistry, 2009 Jun 16. PMID 19402710
  2. High yield cell-free production of integral membrane proteins without refolding or detergents. Wuu JJ, et al. Biochim Biophys Acta, 2008 May. PMID 18295592
  3. Intramolecular domain-domain association/dissociation and phosphoryl transfer in the mannitol transporter of Escherichia coli are not coupled. Suh JY, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360622, Free PMC Article
  4. The oligomeric state and stability of the mannitol transporter, EnzymeII(mtl), from Escherichia coli: a fluorescence correlation spectroscopy study. Veldhuis G, et al. Protein Sci, 2006 Aug. PMID 16823033, Free PMC Article
  5. Stoichiometry and substrate affinity of the mannitol transporter, EnzymeIImtl, from Escherichia coli. Veldhuis G, et al. Biophys J, 2005 Jul. PMID 15879478, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-phosphocysteine-mannitol phosphotransferase system transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-phosphocysteine-sugar phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mannitol transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mannitol transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannitol-specific PTS enzyme IICBA component
NP_418056.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3772281..3774194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418056.1 mannitol-specific PTS enzyme IICBA component [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418056.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EAB5
    Conserved Domains (1) summary
    PRK15083
    Location:1 → 637
    PRK15083; PTS system mannitol-specific transporter subunit IICBA; Provisional
Nucleotide Protein
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