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tdh threonine dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948139, updated on 2-May-2024

Summary

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Gene symbol
tdh
Gene description
threonine dehydrogenase
Primary source
ASAP:ABE-0011830
Locus tag
b3616
See related
ECOCYC:EG10993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3606
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Genomic context

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Sequence:
NC_000913.3 (3790320..3791345, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein hydrolase activator EnvC Neighboring gene divergent polysaccharide deacetylase domain-containing protein YibQ Neighboring gene UDP-glucuronate:LPS(HepIII) glycosyltransferase Neighboring gene 2-amino-3-ketobutyrate CoA ligase Neighboring gene protein HtrL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of E. coli threonine dehydrogenase by means of mutant isolation and characterization. Chen YW, et al. Biochim Biophys Acta, 1995 Dec 6. PMID 8519804
  2. L-threonine dehydrogenase. Purification and properties of the homogeneous enzyme from Escherichia coli K-12. Boylan SA, et al. J Biol Chem, 1981 Feb 25. PMID 6780553
  3. Growth, enzyme levels, and some metabolic properties of an Escherichia coli mutant grown on L-threonine as the sole carbon source. Boylan SA, et al. J Bacteriol, 1983 Oct. PMID 6413491, Free PMC Article
  4. Localization of the structural gene for threonine dehydrogenase in Escherichia coli. Ravnikar PD, et al. J Bacteriol, 1986 Oct. PMID 3531182, Free PMC Article
  5. L-threonine dehydrogenase from Escherichia coli K-12: thiol-dependent activation by Mn2+. Craig PA, et al. Biochemistry, 1986 Apr 22. PMID 3518793

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that peptide deformylase, threonine dehydrogenase, and cytosine deaminase are very sensitve to hydrogen peroxide.
    Title: Mononuclear iron enzymes are primary targets of hydrogen peroxide stress.
  2. N-terminus verified by Edman degradation on complete protein
    Title: The primary structure of Escherichia coli L-threonine dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-threonine 3-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-threonine 3-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables cadmium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-serine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-threonine catabolic process to glycine IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within threonine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
threonine dehydrogenase
NP_418073.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3790320..3791345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418073.1 threonine dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418073.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7M4C7V6, A0A8S7L585
    Conserved Domains (1) summary
    PRK05396
    Location:1 → 341
    tdh; L-threonine 3-dehydrogenase; Validated
Nucleotide Protein
Heading Accession and Version

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