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waaY lipopolysaccharide core heptose (II) kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948145, updated on 25-Jan-2024

Summary

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Gene symbol
waaY
Gene description
lipopolysaccharide core heptose (II) kinase
Primary source
ASAP:ABE-0011856
Locus tag
b3625
See related
ECOCYC:EG11425
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3615; rfaY
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11425].
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Genomic context

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Sequence:
NC_000913.3 (3800267..3800965, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative ADP-heptose:LPS heptosyltransferase 4 Neighboring gene lipopolysaccharide core biosynthesis protein WaaZ Neighboring gene UDP-glucose:(glucosyl)LPS alpha-1,2-glucosyltransferase Neighboring gene UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase Neighboring gene UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility of Escherichia coli to the Human Antimicrobial Peptide LL-37. Bociek K, et al. J Biol Chem, 2015 Aug 7. PMID 26100635, Free PMC Article
  2. Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Yethon JA, et al. J Bacteriol, 2000 Oct. PMID 10986272, Free PMC Article
  3. SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli. Lee JH, et al. J Bacteriol, 2009 Jul. PMID 19376854, Free PMC Article
  4. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Heinrichs DE, et al. Mol Microbiol, 1998 Oct. PMID 9791168
  5. Physical maps of the rfa loci of Escherichia coli K-12 and Salmonella typhimurium. Schnaitman CA, et al. J Bacteriol, 1991 Dec. PMID 1938935, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipopolysaccharide phosphorylation by the WaaY kinase affects the susceptibility of Escherichia coli to the human antimicrobial peptide LL-37.
    Title: Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility of Escherichia coli to the Human Antimicrobial Peptide LL-37.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
lipopolysaccharide core heptose (II) kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3800267..3800965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418082.1 lipopolysaccharide core heptose (II) kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418082.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7M4C7U8
    Conserved Domains (1) summary
    pfam06176
    Location:1 → 229
    WaaY; Lipopolysaccharide core biosynthesis protein (WaaY)
Nucleotide Protein
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