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pyrE orotate phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948157, updated on 2-May-2024

Summary

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Gene symbol
pyrE
Gene description
orotate phosphoribosyltransferase
Primary source
ASAP:ABE-0011904
Locus tag
b3642
See related
ECOCYC:EG10808
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3632
Summary
This enzyme is at a low level in Escherichia coli strains W1485 and its daughters W3110 and MG1655 because of a mutation in the upstream gene affecting transcription of pyrE. [More information is available at EcoCyc: EG10808].
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Genomic context

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Sequence:
NC_000913.3 (3815127..3815768, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase Neighboring gene dUTP diphosphatase Neighboring gene nucleoid occlusion factor SlmA Neighboring gene truncated RNase PH Neighboring gene putative RNase adaptor protein YicC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the Escherichia coli pyrE gene and of the DNA in front of the protein-coding region.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables orotate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotate phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotate phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine ribonucleoside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
orotate phosphoribosyltransferase
NP_418099.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3815127..3815768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418099.1 orotate phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418099.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YIC2
    Conserved Domains (1) summary
    PRK00455
    Location:1 → 213
    pyrE; orotate phosphoribosyltransferase; Validated
Nucleotide Protein
Heading Accession and Version

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