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gltS glutamate:sodium symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948166, updated on 2-May-2024

Summary

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Gene symbol
gltS
Gene description
glutamate:sodium symporter
Primary source
ASAP:ABE-0011941
Locus tag
b3653
See related
ECOCYC:EG10406
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3643; gltC
Summary
Predicted to be in the ST(3) structural class based on hydropathy profile (Lolkema, 2003), but is was not placed in the very similar IT superfamily in a study using phylogenetic methods (Prakash, 2003). [More information is available at EcoGene: EG10406]. Escherichia coli contains four transporters for the uptake of glutamate (GltIJKL, GltP, GltS, and GadC). [More information is available at EcoCyc: EG10406].
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Genomic context

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Sequence:
NC_000913.3 (3827460..3828665, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA (Gm18) 2'-O-methyltransferase Neighboring gene ATP-dependent DNA helicase RecG Neighboring gene xanthine:H(+) symporter XanP Neighboring gene AsmA family protein YicH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional importance of GGXG sequence motifs in putative reentrant loops of 2HCT and ESS transport proteins. Dobrowolski A, et al. Biochemistry, 2009 Aug 11. PMID 19594131
  2. Projection structure by single-particle electron microscopy of secondary transport proteins GltT, CitS, and GltS. Mościcka KB, et al. Biochemistry, 2009 Jul 21. PMID 19518127
  3. Membrane topology of the GltS Na+/glutamate permease of Escherichia coli. Szvetnik A, et al. FEMS Microbiol Lett, 2007 Oct. PMID 17662058
  4. Membrane topology prediction by hydropathy profile alignment: membrane topology of the Na(+)-glutamate transporter GltS. Dobrowolski A, et al. Biochemistry, 2007 Mar 6. PMID 17269795
  5. Utilization of L-glutamic and 2-oxoglutaric acid as sole sources of carbon by Escherichia coli. HALPERN YS, et al. J Gen Microbiol, 1961 Oct. PMID 13904003

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper presents the membrane topology analysis of the GltS.
    Title: Membrane topology of the GltS Na+/glutamate permease of Escherichia coli.
  2. Gel filtration indicates a reversible equilibrium of two oligomeric states in detergent solution that we identified as a trimer and hexamer by blue-native gel electrophoresis and cross-linking.
    Title: Structure and function of prokaryotic glutamate transporters from Escherichia coli and Pyrococcus horikoshii.
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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutamate:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate:sodium symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3827460..3828665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418110.1 glutamate:sodium symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418110.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ACQ5
    Conserved Domains (1) summary
    TIGR00210
    Location:2 → 398
    gltS; sodium--glutamate symport carrier (gltS)
Nucleotide Protein
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