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uhpT hexose-6-phosphate:phosphate antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948201, updated on 11-Apr-2024

Summary

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Gene symbol
uhpT
Gene description
hexose-6-phosphate:phosphate antiporter
Primary source
ASAP:ABE-0011981
Locus tag
b3666
See related
ECOCYC:EG11054
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3657
Summary
UhpT exhanges cytoplasmic phosphate for hexose phosphate. [More information is available at EcoGene: EG11054]. UhpT is a hexose phosphate transporter that is a member of the Major Facilitator Superfamily (MFS) . [More information is available at EcoCyc: EG11054].
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Genomic context

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Sequence:
NC_000913.3 (3845776..3847167, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenine transporter Neighboring gene adenine deaminase Neighboring gene ncRNA Neighboring gene inner membrane protein sensing glucose-6-phosphate Neighboring gene sensory histidine kinase UhpB Neighboring gene DNA-binding transcriptional activator UhpA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates. Ohkoshi Y, et al. Biomed Res Int, 2017. PMID 28197413, Free PMC Article
  2. Altered oxyanion selectivity in mutants of UhpT, the Pi-linked sugar phosphate carrier of Escherichia coli. Hall JA, et al. J Biol Chem, 2005 Feb 4. PMID 15556940
  3. Pyridoxal 5-phosphate inhibition of substrate selectivity mutants of UhpT, the sugar 6-phosphate carrier of Escherichia coli. Hall JA, et al. J Bacteriol, 2002 Jul. PMID 12057975, Free PMC Article
  4. Transmembrane segment 11 of UhpT, the sugar phosphate carrier of Escherichia coli, is an alpha-helix that carries determinants of substrate selectivity. Hall JA, et al. J Biol Chem, 2001 Jul 6. PMID 11349129
  5. Altered substrate selectivity in a mutant of an intrahelical salt bridge in UhpT, the sugar phosphate carrier of Escherichia coli. Hall JA, et al. J Biol Chem, 1999 Mar 5. PMID 10037698

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fosfomycin resistant E. coli mutants contain the deletion of uhpT encoding hexose-6-phosphate antiporter or a nonsense mutation in DNA-binding transcriptional activator UhpA (uhpA). The expression of uhpT is absent in the mutant strains with uhpT deletion and is not inducible in the strain with the uhpA mutation. The mutants have reduced growth on minimal medium supplemented with glucose-6-phosphate.
    Title: Frequency and Mechanisms of Spontaneous Fosfomycin Nonsusceptibility Observed upon Disk Diffusion Testing of Escherichia coli.
  2. eduction of uhpT function is largely responsible for the reduced sensitivity to FOM in clinical isolates that have not acquired FOM-modifying genes or mutations in murA.
    Title: Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates.
  3. Elevated expression of GlpT and UhpT via FNR activation contributes to increased fosfomycin susceptibility in Escherichia coli under anaerobic conditions.
    Title: Elevated Expression of GlpT and UhpT via FNR Activation Contributes to Increased Fosfomycin Susceptibility in Escherichia coli under Anaerobic Conditions.
  4. the Asp388-Lys391 ion pair acts normally as a filter that prevents substrates lacking a proton that can be donated from occupying the UhpT active site.
    Title: Altered oxyanion selectivity in mutants of UhpT, the Pi-linked sugar phosphate carrier of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hexose-phosphate:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hexose phosphate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
hexose-6-phosphate:phosphate antiporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3845776..3847167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418122.1 hexose-6-phosphate:phosphate antiporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418122.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA88EQ09
    Conserved Domains (1) summary
    PRK09556
    Location:2 → 460
    uhpT; hexose-6-phosphate:phosphate antiporter
Nucleotide Protein
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