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wzyE enterobacterial common antigen polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948293, updated on 4-Apr-2024

Summary

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Gene symbol
wzyE
Gene description
enterobacterial common antigen polymerase
Primary source
ASAP:ABE-0012392
Locus tag
b3793
See related
ECOCYC:EG11457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3786; rffT
Summary
Mutants are blocked in ECA synthesis and accumulate Lipid III. [More information is available at EcoGene: EG11457]. wzyE has been proposed to encode the polymerase involved in the assembly of linear ECA polysaccharide chains . [More information is available at EcoCyc: EG11457].
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Genomic context

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Sequence:
NC_000913.3 (3978601..3979953)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase Neighboring gene lipid IIIECA flippase Neighboring gene TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase Neighboring gene UDP-N-acetyl-D-mannosaminuronic acid transferase Neighboring gene putative transporter YifK

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli. Zuo J, et al. Microb Pathog, 2019 Feb. PMID 30553014
  2. Genetic location of genes encoding enterobacterial common antigen. Meier U, et al. J Bacteriol, 1985 Aug. PMID 3894334, Free PMC Article
  3. Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence. Ramos-Morales F, et al. J Bacteriol, 2003 Sep. PMID 12923112, Free PMC Article
  4. The modality of enterobacterial common antigen polysaccharide chain lengths is regulated by o349 of the wec gene cluster of Escherichia coli K-12. Barr K, et al. J Bacteriol, 1999 Oct. PMID 10515954, Free PMC Article
  5. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Furthermore, an LD50 assay revealed that the virulence of mutant strain DE17Deltawzy was attenuated 132-fold compared with wild-type strain DE17.
    Title: The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in enterobacterial common antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enterobacterial common antigen polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3978601..3979953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418241.1 enterobacterial common antigen polymerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418241.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6Q7I8, A0A5B9ANF5
    Conserved Domains (1) summary
    PRK02975
    Location:1 → 450
    PRK02975; O-antigen assembly polymerase
Nucleotide Protein
Heading Accession and Version

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