U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dapE succinyl-diaminopimelate desuccinylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948313, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
dapE
Gene description
succinyl-diaminopimelate desuccinylase
Primary source
ASAP:ABE-0008142
Locus tag
b2472
See related
ECOCYC:EG10208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2467; msgB
Summary
A dapE mutant is not in the Keio collection; DAP auxotrophs require added DAP to grow and since no DAP was added during mutant construction, no auxotrophic mutants were recovered; dapE is not an essential gene (Baba, 2006). dapE(msgB) is a multicopy suppressor of grpE(Ts). [More information is available at EcoGene: EG10208]. The Escherichia coli N-succinyl-L-diaminopimelate desuccinylase exists as a mixture of homodimers and homotetramers. [More information is available at EcoCyc: EG10208].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2591607..2592734)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YpfM Neighboring gene putative reductase YffB Neighboring gene PF13980 family protein YpfN Neighboring gene esterase YpfH

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. Gillner D, et al. Bioorg Med Chem Lett, 2009 Nov 15. PMID 19822427
  2. Bacterial N-succinyl-L-diaminopimelic acid desuccinylase. Purification, partial characterization, and substrate specificity. Lin YK, et al. J Biol Chem, 1988 Feb 5. PMID 3276674
  3. The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE. Wu B, et al. J Bacteriol, 1992 Aug. PMID 1644751, Free PMC Article
  4. The N-succinyl-l,l-diaminopimelic acid desuccinylase DapE acts through ZapB to promote septum formation in Escherichia coli. Du S, et al. Mol Microbiol, 2017 Jul. PMID 28470834, Free PMC Article
  5. Identification of the purC gene product of Escherichia coli. Parker J. J Bacteriol, 1984 Mar. PMID 6365889, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cobalt ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinyl-diaminopimelate desuccinylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinyl-diaminopimelate desuccinylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinyl-diaminopimelate desuccinylase activity IEA
Inferred from Electronic Annotation
more info
  
enables succinyl-diaminopimelate desuccinylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in diaminopimelate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via diaminopimelate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
succinyl-diaminopimelate desuccinylase
NP_416967.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2591607..2592734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416967.1 succinyl-diaminopimelate desuccinylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416967.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C9ABL5, A0A8T5Y6Y3
    Conserved Domains (1) summary
    PRK13009
    Location:2 → 375
    PRK13009; succinyl-diaminopimelate desuccinylase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.