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metE cobalamin-independent homocysteine transmethylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948323, updated on 2-May-2024

Summary

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Gene symbol
metE
Gene description
cobalamin-independent homocysteine transmethylase
Primary source
ASAP:ABE-0012520
Locus tag
b3829
See related
ECOCYC:EG10584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3823; metB12
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Genomic context

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Sequence:
NC_000913.3 (4013053..4015314)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphosugar phosphatase YigL Neighboring gene biotin transporter Neighboring gene DNA-binding transcriptional dual regulator MetR Neighboring gene putative dienelactone hydrolase Neighboring gene uridine phosphorylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolved cobalamin-independent methionine synthase (MetE) improves the acetate and thermal tolerance of Escherichia coli. Mordukhova EA, et al. Appl Environ Microbiol, 2013 Dec. PMID 24123739, Free PMC Article
  2. Mechanism of methionine synthase overexpression in chaperonin-depleted Escherichia coli. Fujiwara K, et al. Microbiology (Reading), 2012 Apr. PMID 22262097
  3. Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli. Hondorp ER, et al. J Bacteriol, 2009 May. PMID 19286805, Free PMC Article
  4. Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase. Taurog RE, et al. Biochemistry, 2006 Apr 25. PMID 16618098, Free PMC Article
  5. Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase. Taurog RE, et al. Biochemistry, 2006 Apr 25. PMID 16618097, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Authors demonstrate improved Escherichia coli growth in the presence of acetate or at elevated temperatures solely due to mutations in the MetE enzyme.
    Title: Evolved cobalamin-independent methionine synthase (MetE) improves the acetate and thermal tolerance of Escherichia coli.
  2. The metE promoter is responsible for the reconstitution of MetE overexpression in GroE-depleted cells.
    Title: Mechanism of methionine synthase overexpression in chaperonin-depleted Escherichia coli.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  4. MetE is one of the proteins in E. coli most susceptible to oxidation
    Title: Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methionine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in homocysteine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methionine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cobalamin-independent homocysteine transmethylase
NP_418273.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4013053..4015314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418273.1 cobalamin-independent homocysteine transmethylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418273.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X691
    Conserved Domains (1) summary
    PRK05222
    Location:2 → 752
    PRK05222; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional
Nucleotide Protein
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