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fre NAD(P)H-flavin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948325, updated on 15-Oct-2023

Summary

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Gene symbol
fre
Gene description
NAD(P)H-flavin reductase
Primary source
ASAP:ABE-0012559
Locus tag
b3844
See related
ECOCYC:EG10334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3836; fadI; flrD; fsrC
Summary
The fre gene was mistakenly thought to be ubiB. [More information is available at EcoGene: EG10334].
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Genomic context

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Sequence:
NC_000913.3 (4026527..4027228)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3' -> 5' ssDNA/RNA exonuclease TatD Neighboring gene transcription antiterminator RfaH Neighboring gene 3-octaprenyl-4-hydroxybenzoate decarboxylase Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fre Is the Major Flavin Reductase Supporting Bioluminescence from Vibrio harveyi Luciferase in Escherichia coli. Campbell ZT, et al. J Biol Chem, 2009 Mar 27. PMID 19139094, Free PMC Article
  2. Complementarity of ensemble and single-molecule measures of protein motion: a relaxation dispersion NMR study of an enzyme complex. Vallurupalli P, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16880391, Free PMC Article
  3. Protein conformational dynamics probed by single-molecule electron transfer. Yang H, et al. Science, 2003 Oct 10. PMID 14551431
  4. Chemistry. The motions of an enzyme soloist. Orrit M. Science, 2003 Oct 10. PMID 14551425
  5. FAD is a preferred substrate and an inhibitor of Escherichia coli general NAD(P)H:flavin oxidoreductase. Louie TM, et al. J Biol Chem, 2002 Oct 18. PMID 12177066

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme.
  2. biochemical analyis of FlRd and its physiological partner, the NADH:flavorubredoxin oxidoreductase FlRd-Red
    Title: Redox and spectroscopic properties of the Escherichia coli nitric oxide-detoxifying system involving flavorubredoxin and its NADH-oxidizing redox partner.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables riboflavin reductase (NAD(P)H) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables riboflavin reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
  
enables riboflavin reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables riboflavin reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)H-flavin reductase
NP_418286.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4026527..4027228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418286.1 NAD(P)H-flavin reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418286.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7CST2
    Conserved Domains (1) summary
    PRK08051
    Location:2 → 233
    fre; FMN reductase; Validated
Nucleotide Protein
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