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hemG protoporphyrinogen oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948331, updated on 2-May-2024

Summary

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Gene symbol
hemG
Gene description
protoporphyrinogen oxidase
Primary source
ASAP:ABE-0012577
Locus tag
b3850
See related
ECOCYC:EG11485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3842; yihB
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Genomic context

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Sequence:
NC_000913.3 (4034608..4035153)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Xaa-Pro dipeptidase Neighboring gene IMPACT family member YigZ Neighboring gene K(+) transporter TrkH Neighboring gene 16S ribosomal RNA Neighboring gene tRNA-Ile

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity. Boynton TO, et al. Biochemistry, 2009 Jul 28. PMID 19583219, Free PMC Article
  2. Non-iron porphyrins cause tumbling to blue light by an Escherichia coli mutant defective in hemG. Yang H, et al. Proc Natl Acad Sci U S A, 1996 Mar 19. PMID 8637896, Free PMC Article
  3. Nucleotide sequence of the hemG gene involved in the protoporphyrinogen oxidase activity of Escherichia coli K12. Sasarman A, et al. Can J Microbiol, 1993 Dec. PMID 7916647
  4. Cloning and identification of the hemG gene encoding protoporphyrinogen oxidase (PPO) of Escherichia coli K-12. Nishimura K, et al. DNA Res, 1995. PMID 7788523
  5. Protoporphyrinogen oxidation, an enzymatic step in heme and chlorophyll synthesis: partial characterization of the reaction in plant organelles and comparison with mammalian and bacterial systems. Jacobs JM, et al. Arch Biochem Biophys, 1984 Feb 15. PMID 6703698

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence of the hemG gene involved in the protoporphyrinogen oxidase activity of Escherichia coli K12.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables menaquinone-dependent protoporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables menaquinone-dependent protoporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables menaquinone-dependent protoporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxygen-dependent protoporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within heme B biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protoporphyrinogen oxidase
NP_418292.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4034608..4035153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418292.1 protoporphyrinogen oxidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418292.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L7EE66
    Conserved Domains (1) summary
    PRK11104
    Location:1 → 178
    hemG; menaquinone-dependent protoporphyrinogen IX dehydrogenase
Nucleotide Protein
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