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mobB molybdopterin-guanine dinucleotide biosynthesis adaptor protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948343, updated on 2-May-2024

Summary

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Gene symbol
mobB
Gene description
molybdopterin-guanine dinucleotide biosynthesis adaptor protein
Primary source
ASAP:ABE-0012591
Locus tag
b3856
See related
ECOCYC:EG11828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3848; yihC
Summary
MobB has a weak intrinsic GTP-binding and GTPase activity that may be enhanced by interaction with MobA. [More information is available at EcoGene: EG11828]. Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11828].
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Genomic context

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Sequence:
NC_000913.3 (4040906..4041433, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene molybdenum cofactor guanylyltransferase Neighboring gene DUF1040 domain-containing protein YihD Neighboring gene stress response kinase A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecules of Escherichia coli MobB assemble into densely packed hollow cylinders in a crystal lattice with 75% solvent content. Rangarajan SE, et al. Acta Crystallogr D Biol Crystallogr, 2003 Dec. PMID 14646116
  2. The product of the molybdenum cofactor gene mobB of Escherichia coli is a GTP-binding protein. Eaves DJ, et al. Eur J Biochem, 1997 Jun 15. PMID 9219527
  3. The mob locus of Escherichia coli K12 required for molybdenum cofactor biosynthesis is expressed at very low levels. Iobbi-Nivol C, et al. Microbiology (Reading), 1995 Jul. PMID 7551035
  4. Involvement of the narJ and mob gene products in distinct steps in the biosynthesis of the molybdoenzyme nitrate reductase in Escherichia coli. Palmer T, et al. Mol Microbiol, 1996 May. PMID 8793883
  5. In vivo interactions between gene products involved in the final stages of molybdenum cofactor biosynthesis in Escherichia coli. Magalon A, et al. J Biol Chem, 2002 Dec 13. PMID 12372836

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The mob locus of Escherichia coli K12 required for molybdenum cofactor biosynthesis is expressed at very low levels.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
molybdopterin-guanine dinucleotide biosynthesis adaptor protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4040906..4041433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418293.2 molybdopterin-guanine dinucleotide biosynthesis adaptor protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418293.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YN48
    Conserved Domains (1) summary
    PRK10751
    Location:2 → 174
    PRK10751; molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials