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corA Ni(2(+))/Co(2(+))/Mg(2(+)) transporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948351, updated on 4-Feb-2024

Summary

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Gene symbol
corA
Gene description
Ni(2(+))/Co(2(+))/Mg(2(+)) transporter
Primary source
ASAP:ABE-0012464
Locus tag
b3816
See related
ECOCYC:EG11463
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3810
Summary
corA mutants are hypersensitivity to lactoperoxidase. otherPDB (T. maritima): [More information is available at EcoGene: EG11463]. CorA is a magnesium ion transporter that is a member of the Metal Ion Transporter (MIT) family . [More information is available at EcoCyc: EG11463].
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Genomic context

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Sequence:
NC_000913.3 (4001426..4002376)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2233 domain-containing protein YigE Neighboring gene protein YsgD Neighboring gene DUF2628 domain-containing protein YigF Neighboring gene inner membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate. Wang SZ, et al. J Biol Chem, 2006 Sep 15. PMID 16835234
  2. Crystal structure of the CorA Mg2+ transporter. Lunin VV, et al. Nature, 2006 Apr 6. PMID 16598263, Free PMC Article
  3. Crystallization and preliminary X-ray diffraction analysis of the magnesium transporter CorA. Payandeh J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Feb 1. PMID 16511288, Free PMC Article
  4. Characterization of lactoperoxidase stress response in Escherichia coli and involvement of corA in lactoperoxidase tolerance. Sermon J, et al. Commun Agric Appl Biol Sci, 2004. PMID 15560183
  5. Possible participation of macrophage inflammatory protein 2 in neutrophil infiltration in allergic inflammation in rats. Xiao YQ, et al. Biochim Biophys Acta, 1997 Aug 22. PMID 9300795

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings reveal an RNase III-mediated regulatory pathway that functions to modulate corA expression and, in turn, the influx of metal ions transported by CorA in E. coli.
    Title: RNase III controls the degradation of corA mRNA in Escherichia coli.
  2. affects the lactoperoxidase sensitivity of E. coli by modulating the cytoplasmic concentrations of transition metals that enhance the toxicity of the lactoperoxidase system
    Title: CorA affects tolerance of Escherichia coli and Salmonella enterica serovar Typhimurium to the lactoperoxidase enzyme system but not to other forms of oxidative stress.
  3. the E. coli CorA periplasmic domain functions as a homotetramer for binding substrate
    Title: Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cobalt ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cobalt ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalt ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables cobalt ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nickel cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cobalt ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cobalt ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within magnesium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in magnesium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within magnesium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nickel cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
Ni(2(+))/Co(2(+))/Mg(2(+)) transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4001426..4002376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418260.1 Ni(2(+))/Co(2(+))/Mg(2(+)) transporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418260.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ABZ7
    Conserved Domains (1) summary
    PRK11085
    Location:1 → 316
    PRK11085; magnesium/cobalt transporter CorA
Nucleotide Protein
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