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hemN coproporphyrinogen III dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948362, updated on 2-May-2024

Summary

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Gene symbol
hemN
Gene description
coproporphyrinogen III dehydrogenase
Primary source
ASAP:ABE-0012629
Locus tag
b3867
See related
ECOCYC:EG11836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3860; yihJ
Summary
Radical SAM superfamily. [More information is available at EcoGene: EG11836]. Escherichia coli contains two coproporphyrinogen III oxidases, one that is active under aerobic conditions, the hemF gene product, and one that is active under anaerobic conditions, the hemN gene product . [More information is available at EcoCyc: EG11836].
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Genomic context

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Sequence:
NC_000913.3 (4052045..4053418)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Der GTPase-activating protein YihI Neighboring gene uncharacterized protein YshB Neighboring gene DNA-binding transcriptional dual regulator NtrC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN. Layer G, et al. J Biol Chem, 2006 Jun 9. PMID 16606627
  2. Radical S-adenosylmethionine enzyme coproporphyrinogen III oxidase HemN: functional features of the [4Fe-4S] cluster and the two bound S-adenosyl-L-methionines. Layer G, et al. J Biol Chem, 2005 Aug 12. PMID 15967800
  3. Structure and function of radical SAM enzymes. Layer G, et al. Curr Opin Chem Biol, 2004 Oct. PMID 15450488
  4. Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes. Layer G, et al. EMBO J, 2003 Dec 1. PMID 14633981, Free PMC Article
  5. Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli. Layer G, et al. J Biol Chem, 2002 Sep 13. PMID 12114526

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables coproporphyrinogen dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables coproporphyrinogen dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables coproporphyrinogen dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables coproporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protoporphyrinogen IX biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coproporphyrinogen III dehydrogenase
NP_418303.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4052045..4053418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418303.2 coproporphyrinogen III dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418303.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827Y316, C3SJQ7
    Conserved Domains (1) summary
    PRK09249
    Location:4 → 457
    PRK09249; coproporphyrinogen dehydrogenase
Nucleotide Protein
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