fpr flavodoxin/ferredoxin-NADP(+) reductase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: fpr
Gene description: flavodoxin/ferredoxin-NADP(+) reductase
Primary source: ASAP:ABE-0012818
Locus tag: b3924
See related: ECOCYC:EG10628
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3916; flxR; mvrA
Summary: The anaerobic nucleoside-triphosphate reductase activating system is composed of three enzymes and several compounds. [More information is available at EcoCyc: EG10628].
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NC_000913.3 Genomic Context describing neighboring genes

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A new catalytic mechanism of bacterial ferredoxin-NADP(+) reductases due to a particular NADP(+) binding mode.
Title: A new catalytic mechanism of bacterial ferredoxin-NADP(+) reductases due to a particular NADP(+) binding mode.
investigation of flavin-independent Fenton reaction system; NfnB and Fpr were purified and showed catalytic activities of ferric reduction; characterization of these enzymes and their involvement in the Fenton reaction and ferric reduction are presented
Title: Escherichia coli ferredoxin-NADP+ reductase and oxygen-insensitive nitroreductase are capable of functioning as ferric reductase and of driving the Fenton reaction.
N-terminus verified by Edman degradation on mature peptide
Title: Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein.
G6PDH and FPR could act concertedly to deliver reducing equivalents from carbohydrates, via NADP(+), to the FPR acceptors ferredoxin and/or flavodoxin.
Title: Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferredoxin-NADP+ reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferredoxin-NADP+ reductase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron-sulfur cluster assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to superoxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_418359.1

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