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menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948418, updated on 2-May-2024

Summary

Gene symbol
menA
Gene description
1,4-dihydroxy-2-naphthoate octaprenyltransferase
Primary source
ASAP:ABE-0012841
Locus tag
b3930
See related
ECOCYC:EG11880
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3922; yiiW
Summary
1,4-dihydroxy-2-naphthoate octaprenyltransferase catalyzes the transfer of an octaprenyl side chain to DHNA, the reaction in menaquinone biosynthesis where the pathway becomes associated with the membrane . [More information is available at EcoCyc: EG11880].
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Genomic context

Sequence:
NC_000913.3 (4119423..4120349, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division factor ZapB Neighboring gene ribonuclease E inhibitor protein A Neighboring gene ATPase component of the HslVU protease Neighboring gene peptidase component of the HslVU protease

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in menaquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in menaquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within menaquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in quinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vitamin K biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
1,4-dihydroxy-2-naphthoate octaprenyltransferase
NP_418365.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4119423..4120349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418365.1 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418365.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1D7PUJ6, A0A1X3I0L3, A0A1X3IUF3, A0A1X3JAB1, A0A8E0FQC4, F4V8S7, F4VLK0
    Conserved Domains (1) summary
    TIGR00751
    Location:17300
    menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase