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pflC putative pyruvate formate-lyase 2 activating enzyme PflC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948453, updated on 2-May-2024

Summary

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Gene symbol
pflC
Gene description
putative pyruvate formate-lyase 2 activating enzyme PflC
Primary source
ASAP:ABE-0012937
Locus tag
b3952
See related
ECOCYC:EG11911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3943; yijM
Summary
Radical SAM superfamily. [More information is available at EcoGene: EG11911]. PflC was identified by sequence similarity as a homolog of pyruvate formate-lyase activating enzyme . [More information is available at EcoCyc: EG11911].
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Genomic context

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Sequence:
NC_000913.3 (4146258..4147136)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative PTS enzyme IIC component FrwC Neighboring gene putative PTS enzyme IIB component FrwB Neighboring gene putative formate acetyltransferase 2 Neighboring gene putative PTS enzyme IIB component FrwD Neighboring gene putative DNA-binding transcriptional regulator YijO Neighboring gene phosphoethanolamine transferase EptC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Promoter 7 of the Escherichia coli pfl operon is a major determinant in the anaerobic regulation of expression by ArcA. Drapal N, et al. J Bacteriol, 1995 Sep. PMID 7665524, Free PMC Article
  2. Fumarate reductase mutants of Escherichia coli that lack covalently bound flavin. Blaut M, et al. J Biol Chem, 1989 Aug 15. PMID 2668268
  3. Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system. Reizer J, et al. Microbiology (Reading), 1995 Apr. PMID 7773398
  4. The effect of pfl gene knockout on the metabolism for optically pure D-lactate production by Escherichia coli. Zhu J, et al. Appl Microbiol Biotechnol, 2004 Apr. PMID 14673546
  5. Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Blattner FR, et al. Nucleic Acids Res, 1993 Nov 25. PMID 8265357, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables [formate-C-acetyltransferase]-activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative pyruvate formate-lyase 2 activating enzyme PflC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4146258..4147136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418387.3 putative pyruvate formate-lyase 2 activating enzyme PflC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418387.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7BFR1, A0A8S7EIZ6, A0AA87ELI1
    Conserved Domains (1) summary
    PRK10076
    Location:80 → 292
    PRK10076; pyruvate formate lyase II activase; Provisional
Nucleotide Protein
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