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argC N-acetylglutamylphosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948455, updated on 2-May-2024

Summary

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Gene symbol
argC
Gene description
N-acetylglutamylphosphate reductase
Primary source
ASAP:ABE-0012964
Locus tag
b3958
See related
ECOCYC:EG10065
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
Arg2; ECK3949
Summary
N-acetylglutamylphosphate reductase (ArgC) carries out the third step in arginine biosynthesis and its subpathway, ornithine biosynthesis. [More information is available at EcoCyc: EG10065].
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Genomic context

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Sequence:
NC_000913.3 (4155001..4156005)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoenolpyruvate carboxylase Neighboring gene acetylornithine deacetylase Neighboring gene acetylglutamate kinase Neighboring gene argininosuccinate lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli. BAICH A, et al. Biochem Biophys Res Commun, 1962 Jun 4. PMID 13863980
  2. The C-terminal end of AraC tightly binds to the rest of its domain. Harmer TL, et al. J Biol Chem, 2001 Feb 16. PMID 11104764
  3. The regulatory region of the divergent argECBH operon in Escherichia coli K-12. Piette J, et al. Nucleic Acids Res, 1982 Dec 20. PMID 6761650, Free PMC Article
  4. Promoter mapping and selection of operator mutants by using insertion of bacteriophage Mu in the argECBH divergent operon of Escherichia coli K-12. Beny G, et al. J Bacteriol, 1982 Jul. PMID 6211434, Free PMC Article
  5. Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes. Parsot C, et al. Gene, 1988 Sep 7. PMID 2851495

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetyl-gamma-glutamyl-phosphate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within arginine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylglutamylphosphate reductase
NP_418393.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4155001..4156005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418393.1 N-acetylglutamylphosphate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418393.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7H9QVH9
    Conserved Domains (1) summary
    PRK00436
    Location:1 → 333
    argC; N-acetyl-gamma-glutamyl-phosphate reductase; Validated
Nucleotide Protein
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