sthA soluble pyridine nucleotide transhydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: sthA
Gene description: soluble pyridine nucleotide transhydrogenase
Primary source: ASAP:ABE-0012975
Locus tag: b3962
See related: ECOCYC:EG11428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3954; sth; udhA
Summary: Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11428]. Escherichia coli contains both a soluble and a membrane-bound proton-translocating pyridine nucleotide transhydrogenase. [More information is available at EcoCyc: EG11428].
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NC_000913.3 Genomic Context describing neighboring genes

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Distinct transcription factors regulated the PntA, PntB and UdhA promoters.
Title: Distinct transcriptional regulation of the two Escherichia coli transhydrogenases PntAB and UdhA.
STH displayed maximal activity at 35 degrees C, pH 7.5. and was stable at 4 degrees C for 25 days.
Title: Overexpression and biochemical characterization of soluble pyridine nucleotide transhydrogenase from Escherichia coli.
The XAFS analysis of transhydrogenase has identified a Zn(2+)-binding cluster formed by one Cys, two His, and one Asp/Glu residue, arranged in a tetrahedral geometry.
Title: X-ray absorption studies of Zn(2+)-binding sites in Escherichia coli transhydrogenase and its betaH91K mutant.
N-terminus verified by Edman degradation on mature peptide
Title: The udhA gene of Escherichia coli encodes a soluble pyridine nucleotide transhydrogenase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD(P)+ transhydrogenase (B-specific) activity	IEA Inferred from Electronic Annotation more info
enables NAD(P)+ transhydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD(P)+ transhydrogenase activity	IEA Inferred from Electronic Annotation more info
enables dihydrolipoyl dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_418397.2

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