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argB acetylglutamate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948464, updated on 2-May-2024

Summary

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Gene symbol
argB
Gene description
acetylglutamate kinase
Primary source
ASAP:ABE-0012967
Locus tag
b3959
See related
ECOCYC:EG10064
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3950
Summary
Acetylglutamate kinase (ArgB) catalyzes the second step in ornithine and arginine biosynthesis. [More information is available at EcoCyc: EG10064].
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Genomic context

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Sequence:
NC_000913.3 (4156013..4156789)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene acetylornithine deacetylase Neighboring gene N-acetylglutamylphosphate reductase Neighboring gene argininosuccinate lyase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The course of phosphorus in the reaction of N-acetyl-L-glutamate kinase, determined from the structures of crystalline complexes, including a complex with an AlF(4)(-) transition state mimic. Gil-Ortiz F, et al. J Mol Biol, 2003 Aug 1. PMID 12875848
  2. A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase. Gil-Ortiz F, et al. Acta Crystallogr D Biol Crystallogr, 2002 Oct. PMID 12351849
  3. Structure of acetylglutamate kinase, a key enzyme for arginine biosynthesis and a prototype for the amino acid kinase enzyme family, during catalysis. Ramón-Maiques S, et al. Structure, 2002 Mar. PMID 12005432
  4. The role of rigidity in DNA looping-unlooping by AraC. Harmer T, et al. Proc Natl Acad Sci U S A, 2001 Jan 16. PMID 11209047, Free PMC Article
  5. N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms. Gil F, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jul. PMID 10393305

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetylglutamate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglutamate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylglutamate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within arginine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process via ornithine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetylglutamate kinase
NP_418394.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4156013..4156789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418394.3 acetylglutamate kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418394.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377E064, A0A8T5ZAM0
    Conserved Domains (1) summary
    cd04249
    Location:5 → 256
    AAK_NAGK-NC; N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of ornithine ...
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases