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coaA pantothenate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948479, updated on 2-May-2024

Summary

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Gene symbol
coaA
Gene description
pantothenate kinase
Primary source
ASAP:ABE-0013003
Locus tag
b3974
See related
ECOCYC:EG10922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3966; panK; rts; ts-9
Summary
Pantothenate kinase catalyzes the first step in the biosynthesis of coenzyme A, an essential cofactor that is involved in many reactions. [More information is available at EcoCyc: EG10922].
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Genomic context

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Sequence:
NC_000913.3 (4174076..4175026, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene UDP-N-acetylenolpyruvoylglucosamine reductase Neighboring gene DNA-binding transcriptional repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA Neighboring gene tRNA-Thr Neighboring gene tRNA-Tyr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic studies of the role of fatty acid and coenzyme A in photocatalytic inactivation of Escherichia coli. Gao M, et al. Water Res, 2012 Sep 1. PMID 22691444
  2. One-pot chemo-enzymatic synthesis of reporter-modified proteins. Worthington AS, et al. Org Biomol Chem, 2006 Jan 7. PMID 16357994
  3. Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Virga KG, et al. Bioorg Med Chem, 2006 Feb 15. PMID 16213731
  4. Enhanced isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli. Vadali RV, et al. Biotechnol Prog, 2004 May-Jun. PMID 15176870
  5. The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. Ivey RA, et al. J Biol Chem, 2004 Aug 20. PMID 15136582

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that while the lower coenzyme A level in coaA(-) mutant correlated well with its lower susceptibility towards photocatalytic inactivation.
    Title: Genetic studies of the role of fatty acid and coenzyme A in photocatalytic inactivation of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantetheine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pantothenate kinase
NP_418405.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4174076..4175026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418405.1 pantothenate kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418405.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7DXX5, A0A830SNX8
    Conserved Domains (1) summary
    TIGR00554
    Location:27 → 316
    panK_bact; pantothenate kinase, bacterial type
Nucleotide Protein
Heading Accession and Version

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