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purH bifunctional AICAR transformylase/IMP cyclohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948503, updated on 4-Apr-2024

Summary

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Gene symbol
purH
Gene description
bifunctional AICAR transformylase/IMP cyclohydrolase
Primary source
ASAP:ABE-0013097
Locus tag
b4006
See related
ECOCYC:EG10795
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3998
Summary
From the earliest studies an association between AICAR transformylase and IMP cyclohydrolase has been shown. [More information is available at EcoCyc: EG10795].
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Genomic context

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Sequence:
NC_000913.3 (4205943..4207532, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase ZraS Neighboring gene DNA-binding transcriptional activator ZraR Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene 16S ribosomal RNA Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli. Qiu X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Dec 1. PMID 22139174, Free PMC Article
  2. Purine biosynthesis in Escherichia coli K12: structure and DNA sequence studies of the purHD locus. Flannigan KA, et al. Mol Microbiol, 1990 Mar. PMID 2192230
  3. Fine mapping of the rrnE, purHD, and hydGH operons on the Escherichia coli chromosome. Peterson JW, et al. J Bacteriol, 1991 Jun. PMID 2045358, Free PMC Article
  4. The effect of DnaA protein levels and the rate of initiation at oriC on transcription originating in the ftsQ and ftsA genes: in vivo experiments. Masters M, et al. Mol Gen Genet, 1989 Apr. PMID 2546042
  5. P-BOSS: a new filtering method for treasure hunting in metabolomics. Morohashi M, et al. J Chromatogr A, 2007 Aug 3. PMID 17400234

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystals of PurH diffracted to a maximum resolution of 3.05 A and belonged to the monoclinic space group P2(1), with unit-cell parameters a = 76.37, b = 132.15, c = 82.64 A, beta = 111.86 degrees
    Title: Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables IMP cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bifunctional AICAR transformylase/IMP cyclohydrolase
NP_418434.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4205943..4207532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418434.1 bifunctional AICAR transformylase/IMP cyclohydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418434.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YJ38, A0AA88EWR8
    Conserved Domains (1) summary
    PRK00881
    Location:4 → 529
    purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional
Nucleotide Protein
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