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plsB glycerol-3-phosphate 1-O-acyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948541, updated on 23-Nov-2023

Summary

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Gene symbol
plsB
Gene description
glycerol-3-phosphate 1-O-acyltransferase
Primary source
ASAP:ABE-0013232
Locus tag
b4041
See related
ECOCYC:EG10740
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4033
Summary
HT_Cmplx46_Mem: [More information is available at EcoGene: EG10740]. Membrane-bound glycerol-3-phosphate acyltransferase catalyzes the first step in phospholipid biosynthesis. [More information is available at EcoCyc: EG10740].
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Genomic context

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Sequence:
NC_000913.3 (4254043..4256466, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chorismate lyase Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene diacylglycerol kinase Neighboring gene DNA-binding transcriptional repressor LexA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli. Noga MJ, et al. mBio, 2020 Aug 18. PMID 32817111, Free PMC Article
  2. A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant. Heath RJ, et al. J Bacteriol, 1999 Mar. PMID 10074094, Free PMC Article
  3. Role of spermidine in the activity of sn-glycerol-3-phosphate acyltransferase from Escherichia coli. Vallari DS, et al. Arch Biochem Biophys, 1982 Oct 15. PMID 6760815
  4. The triose-phosphate site of homogeneous reconstituted sn-glycerol-3-phosphate acyltransferase of Escherichia coli. Green PR, et al. Biochim Biophys Acta, 1984 Sep 12. PMID 6383480
  5. Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase. Green PR, et al. J Biol Chem, 1983 Sep 25. PMID 6350296

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli.
    Title: Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli.
  2. PlsB activation by RpoE is concomitant with a reduced DgkA amount.
    Title: Antagonistic regulation of dgkA and plsB genes of phospholipid synthesis by multiple stress responses in Escherichia coli.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate 1-O-acyltransferase
NP_418465.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4254043..4256466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418465.4 glycerol-3-phosphate 1-O-acyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418465.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5N8HAJ7, A0A6C9Q5C8, A0A8S7HY63, A0A8S7JX96
    Conserved Domains (1) summary
    PRK04974
    Location:1 → 806
    PRK04974; glycerol-3-phosphate 1-O-acyltransferase PlsB
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials