aphA acid phosphatase/phosphotransferase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: aphA
Gene description: acid phosphatase/phosphotransferase
Primary source: ASAP:ABE-0013283
Locus tag: b4055
See related: ECOCYC:EG11934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK4047; hobH; yjbP
Summary: Mutants arrest cell division after hyperosmoshock and overexpress SeqA; also binds hemi-methylated oriC DNA in vitro. [More information is available at EcoGene: EG11934]. Escherichia coli contains a periplasmic acid phosphatase/phosphotransferase. [More information is available at EcoCyc: EG11934].
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NC_000913.3 Genomic Context describing neighboring genes

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The present work reports the crystal structures of AphA from E. coli in complex with substrate, transition-state, and intermediate analogues.
Title: Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases.
An ushA aphA double knockout mutant was shown to be unable to grow on purine nucleotides as the sole carbon source.
Title: Complete deficiency of 5'-nucleotidase activity in Escherichia coli leads to loss of growth on purine nucleotides but not of their excretion.
N-terminus verified by Edman degradation on mature peptide
Title: Hemi-methylated oriC DNA binding activity found in non-specific acid phosphatase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-phosphoserine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in outer membrane-bounded periplasmic space	IDA Inferred from Direct Assay more info	PubMed
located_in outer membrane-bounded periplasmic space	IEA Inferred from Electronic Annotation more info
located_in periplasmic space	IEA Inferred from Electronic Annotation more info

NP_418479.1

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The following sections contain reference sequences that belong to a specific genome build. Explain