U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

acs acetyl-CoA synthetase (AMP-forming) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948572, updated on 2-May-2024

Summary

Go to the top of the page Help
Gene symbol
acs
Gene description
acetyl-CoA synthetase (AMP-forming)
Primary source
ASAP:ABE-0013337
Locus tag
b4069
See related
ECOCYC:EG11448
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
acsA; ECK4062; yfaC
Summary
CRP-cAMP regulon. [More information is available at EcoGene: EG11448]. There are two distinct pathways by which Escherichia coli activates acetate to acetyl-CoA. [More information is available at EcoCyc: EG11448].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (4285413..4287371, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pentapeptide repeat-containing protein YjcF Neighboring gene acetate/glycolate:cation symporter Neighboring gene DUF485 domain-containing inner membrane protein YjcH Neighboring gene protein YtcB Neighboring gene cytochrome c552 nitrite reductase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of acetyl-CoA synthetase kinetics and ATP-binding. Gallego-Jara J, et al. Biochim Biophys Acta Gen Subj, 2019 Jun. PMID 30928490
  2. sigma(70) is the principal sigma factor responsible for transcription of acs, which encodes acetyl coenzyme A synthetase in Escherichia coli. Kumari S, et al. J Bacteriol, 2000 Jan. PMID 10629211, Free PMC Article
  3. Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli. Kumari S, et al. J Bacteriol, 1995 May. PMID 7751300, Free PMC Article
  4. An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli. Castaño-Cerezo S, et al. Microb Cell Fact, 2009 Oct 24. PMID 19852855, Free PMC Article
  5. Acetylation of the chemotaxis response regulator CheY by acetyl-CoA synthetase purified from Escherichia coli. Barak R, et al. J Mol Biol, 2004 Sep 10. PMID 15327942

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acetyl-CoA synthetase (AMP-forming)
NP_418493.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4285413..4287371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418493.1 acetyl-CoA synthetase (AMP-forming) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418493.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JRM4, A0AA90FPG0
    Conserved Domains (1) summary
    PRK00174
    Location:6 → 649
    PRK00174; acetyl-CoA synthetase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.