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fdhF formate dehydrogenase H [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948584, updated on 4-Apr-2024

Summary

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Gene symbol
fdhF
Gene description
formate dehydrogenase H
Primary source
ASAP:ABE-0013363
Locus tag
b4079
See related
ECOCYC:EG10285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlF; ECK4072
Summary
Formate dehydrogenase-H is one of three formate dehydrogenases in Escherichia coli . [More information is available at EcoCyc: EG10285].
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Genomic context

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Sequence:
NC_000913.3 (4297219..4299366, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutamate/aspartate : H(+) symporter GltP Neighboring gene Sel1 repeat-containing protein YjcO Neighboring gene putative multidrug efflux pump outer membrane channel Neighboring gene putative multidrug efflux pump subunit MdtO Neighboring gene putative multidrug efflux pump membrane fusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Understanding the Role of Escherichia coli Hydrogenases and Formate Dehydrogenases in the F(O) F(1) -ATPase Activity during the Mixed Acid Fermentation of Mixture of Carbon Sources. Gevorgyan H, et al. IUBMB Life, 2018 Oct. PMID 30161297
  2. Reaction mechanism of molybdoenzyme formate dehydrogenase. Leopoldini M, et al. Chemistry, 2008. PMID 18671310
  3. Formate-reduced E. coli formate dehydrogenase H: The reinterpretation of the crystal structure suggests a new reaction mechanism. Raaijmakers HC, et al. J Biol Inorg Chem, 2006 Oct. PMID 16830149
  4. Regulation of Escherichia coli formate hydrogenlyase activity by formate at alkaline pH. Mnatsakanyan N, et al. Curr Microbiol, 2002 Oct. PMID 12192527
  5. Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Khangulov SV, et al. Biochemistry, 1998 Mar 10. PMID 9521673

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Urate-degrading activity has been identified in E. coli that is operational under microaerobic and anaerobic conditions. This activity requires formate, formate dehydrogenase H, and either aegA or ygfT.
    Title: Identification of a Formate-Dependent Uric Acid Degradation Pathway in Escherichia coli.
  2. fDH and Hyd enzymes have impact on the FO F1 -ATPase activity depending on external pH and potassium ions
    Title: Understanding the Role of Escherichia coli Hydrogenases and Formate Dehydrogenases in the F(O) F(1) -ATPase Activity during the Mixed Acid Fermentation of Mixture of Carbon Sources.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in formate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in formate oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formate oxidation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glucose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within urate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of formate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of formate dehydrogenase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oxidoreductase complex IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
formate dehydrogenase H

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4297219..4299366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418503.1 formate dehydrogenase H [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418503.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A828MW10
    Conserved Domains (1) summary
    TIGR01591
    Location:6 → 685
    Fdh-alpha; formate dehydrogenase, alpha subunit, archaeal-type
Nucleotide Protein
Heading Accession and Version

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