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phnN ribose 1,5-bisphosphate phosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948608, updated on 4-Apr-2024

Summary

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Gene symbol
phnN
Gene description
ribose 1,5-bisphosphate phosphokinase
Primary source
ASAP:ABE-0013417
Locus tag
b4094
See related
ECOCYC:EG10723
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4087
Summary
Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10723]. The phnN gene encodes ribose 1,5-bisphosphokinase, which catalyzes the final step in a pathway of 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) biosynthesis . [More information is available at EcoCyc: EG10723].
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Genomic context

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Sequence:
NC_000913.3 (4315525..4316082, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YjdP Neighboring gene 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase Neighboring gene aminoalkylphosphonate N-acetyltransferase Neighboring gene RPnTP hydrolase Neighboring gene methylphosphonate degradation complex subunit PhnL Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A fluorescent substrate for carbon-phosphorus lyase: towards the pathway for organophosphonate metabolism in bacteria. He SM, et al. Bioorg Med Chem Lett, 2009 Oct 15. PMID 19733071
  2. Accumulation of intermediates of the carbon-phosphorus lyase pathway for phosphonate degradation in phn mutants of Escherichia coli. Hove-Jensen B, et al. J Bacteriol, 2010 Jan. PMID 19854894, Free PMC Article
  3. Genes for phosphonate biodegradation in Escherichia coli. Wanner BL. SAAS Bull Biochem Biotechnol, 1992 Jan. PMID 1368181
  4. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. Metcalf WW, et al. J Bacteriol, 1991 Jan. PMID 1846145, Free PMC Article
  5. Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways. Hove-Jensen B, et al. J Bacteriol, 2003 May. PMID 12700258, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribose 1,5-bisphosphate phosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose 1,5-bisphosphate phosphokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribose 1,5-bisphosphate phosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in organic phosphonate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic phosphonate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribose 1,5-bisphosphate phosphokinase
NP_418518.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4315525..4316082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418518.1 ribose 1,5-bisphosphate phosphokinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418518.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827Y8V3
    Conserved Domains (1) summary
    PRK10078
    Location:2 → 185
    PRK10078; ribose 1,5-bisphosphokinase; Provisional
Nucleotide Protein
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